{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T23:47:07Z","timestamp":1724543227506},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>AV Nodal Remodeling Induced by AF<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An animal experiment showed that long\u2010term atrial pacing or persistent atrial fibrillation (AF) caused electrical remodeling of the atrioventricular (AV) node. We aimed to test the hypothesis that persistent AF decreases the AV conductivity in human hearts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>We retrospectively compared the cardiac electrophysiological properties between patients with paroxysmal AF who underwent catheter ablation (PXAF, N = 254) and those with persistent or longstanding persistent AF (PSAF, N = 213). The PSAF patients were more likely than PXAF patients to have longer atrial\u2010His (AH) (96.3 \u00b1 25.7 vs. 91.3 \u00b1 20.4 milliseconds; P = 0.02) and His\u2010ventricle (HV) (43.1 \u00b1 9.4 vs. 41.2 \u00b1 8.6 milliseconds; P = 0.02) intervals. The AV nodal effective refractory period (ERP) (299.1 \u00b1 74.6 vs. 276.2 \u00b1 58.9 milliseconds; P &lt; 0.001) and Wenckebach cycle length (420.9 \u00b1 80.3 vs. 386 \u00b1 58.6 milliseconds; P &lt; 0.001) were also more prolonged in the PSAF patients. We found a dual AV nodal physiology with a similar frequency in both groups. The AH interval, fast pathway ERP, and Wenckebach cycle length in the PSAF patients were more likely than in the PXAF patients to be prolonged among the patients without dual pathways, while those intergroup differences were never seen among the patients with dual pathways. In subgroup analyses including only PSAF patients, there was no difference in the AV conductivity between the patients with persistent AF and those with longstanding persistent AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persistent AF may cause a mild decrease in the AV nodal function in human hearts. Electrical remodeling may be uncommon if dual AV nodal pathways are present, and its extent may not depend on the duration of persistent AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.12996","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T10:45:36Z","timestamp":1461235536000},"page":"918-922","source":"Crossref","is-referenced-by-count":5,"title":["Electrical Remodeling of the Atrioventricular Node Caused by Persistent Atrial Fibrillation in Humans"],"prefix":"10.1111","volume":"27","author":[{"given":"AKINORI","family":"SAIRAKU","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YUKIKO","family":"NAKANO","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAZUYOSHI","family":"SUENARI","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TAKEHITO","family":"TOKUYAMA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROSHI","family":"KAWAZOE","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIROYA","family":"MATSUMURA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHUNSUKE","family":"TOMOMORI","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHITAKA","family":"AMIOKA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YASUKI","family":"KIHARA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.616011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12445"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1954"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.130388"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2003.1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20700"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-011-9656-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.180199"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.04.019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2012.07.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.10.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.61.4.309"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.32.3.386"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12996","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.12996","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.12996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:10:55Z","timestamp":1695719455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.12996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/jce.12996"],"URL":"https:\/\/doi.org\/10.1111\/jce.12996","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]}}}