{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:58:24Z","timestamp":1792083504258,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Low Voltage\u2010Based Ablation for Atrial Fibrillation<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low\u2010voltage zones (LVZs) represent fibrotic tissue and are substrates for atrial fibrillation (AF). We hypothesized that LVZ\u2010based substrate modification along with pulmonary vein isolation (PVI) would improve outcomes in persistent AF (PeAF) patients with LVZs, whereas PVI alone would work in patients without LVZs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Voltage mapping of the left atrium (LA) was performed during sinus rhythm in 101 PeAF patients in whom LVZ was defined as an area with bipolar electrograms &lt;0.5 mV. Thirty\u2010nine patients had LVZs and underwent ablation of the entire LVZ area after PVI (LVZabl group). In the remaining 62 patients without LVZs, PVI alone was performed with no further substrate modifications (PVI group). An additional group of 16 consecutive PeAF patients with LVZ did not undergo any substrate modification after PVI and were used as a comparison group (LVZnon\u2010abl group) despite having similar size of LVZs to that in the LVZabl group. After a single session, 28 (72%) patients in the LVZabl group had no recurrence, whereas 49 (79%) patients in the PVI group had no recurrence during 18 \u00b1 7 months of follow\u2010up (log\u2010rank, P = 0.400). In the LVZnon\u2010abl group, only 6 patients (38%) had no recurrence during 32 \u00b1 7 months of follow\u2010up, even after a mean number of sessions of 1.8 (log\u2010rank, P &lt; 0.001, compared with the LVZabl group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Additional LVZ\u2010based substrate modification after PVI improved the outcome in PeAF patients with LVZs, whereas PVI alone worked in patients without LVZs, even in those with PeAF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.13019","type":"journal-article","created":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T04:32:47Z","timestamp":1464409967000},"page":"1055-1063","source":"Crossref","is-referenced-by-count":172,"title":["Efficacy of Left Atrial Voltage\u2010Based Catheter Ablation of Persistent Atrial Fibrillation"],"prefix":"10.1111","volume":"27","author":[{"given":"TAKANORI","family":"YAMAGUCHI","sequence":"first","affiliation":[{"name":"Department of Cardiology Saga\u2010ken Medical Centre Koseikan  Saga Japan"},{"name":"EP Expert Doctors\u2010Team Tsuchiya  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAKESHI","family":"TSUCHIYA","sequence":"additional","affiliation":[{"name":"EP Expert Doctors\u2010Team Tsuchiya  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SHIRO","family":"NAKAHARA","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dokkyo Medical University Koshigaya Hospital  Koshigaya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AKIRA","family":"FUKUI","sequence":"additional","affiliation":[{"name":"EP Expert Doctors\u2010Team Tsuchiya  Kumamoto 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