{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:21:37Z","timestamp":1771665697820,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Histopathological Study of Atria in Rheumatic Mitral Stenosis With Respect to Rhythm<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mitral stenosis (MS) has the highest incidence of atrial fibrillation (AF) in chronic rheumatic valvular disease. There are very few studies in isolated MS comparing histopathological changes in patients with sinus rhythm (SR) and AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the histological changes associated with isolated MS and compare between changes in AF and SR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study in patients undergoing valve replacement surgery for symptomatic isolated MS who were divided into 2 groups, Group I AF (n = 13) and Group II SR (n = 10). Intra\u2010operative biopsies performed from 5 different sites from both atria were analyzed for 10 histopathologic changes commonly associated with AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On multivariate analysis, myocytolysis (odds ratio [OR]: 1.48, P = 0.05) was found to be associated with AF, whereas myocyte hypertrophy (OR: 0.21, P = 0.003), and glycogen deposition (OR: 0.43, P = 0.002) was associated with SR. Interstitial fibrosis the commonest change was uniformly distributed across both atria irrespective of the rhythm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In rheumatic MS, SR is associated with myocyte hypertrophy whereas AF is associated with myocytolysis. Endocardial inflammation is more common in left atrial appendage irrespective of rhythm. Interstitial fibrosis is seen in &gt;90% of patients distributed in both the atria and is independent of the rhythm. Amyloid and Aschoff bodies are uncommon and the rest of the changes are uniformly distributed across both the atria.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13024","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T09:17:18Z","timestamp":1464945438000},"page":"1047-1054","source":"Crossref","is-referenced-by-count":13,"title":["Histopathological Study of Left and Right Atria in Isolated Rheumatic Mitral Stenosis With and Without Atrial Fibrillation"],"prefix":"10.1111","volume":"27","author":[{"given":"JAYAPRAKASH","family":"SHENTHAR","sequence":"first","affiliation":[{"name":"Electrophysiology Unit, Department of Cardiology Sri Jayadeva Institute of Cardiovascular Sciences and Research  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SALIGRAMA RAMEGOWDA","family":"KALPANA","sequence":"additional","affiliation":[{"name":"Department of Pathology Sri Jayadeva Institute of Cardiovascular Sciences and Research  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MUKUND A.","family":"PRABHU","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit, Department of Cardiology Sri Jayadeva Institute of Cardiovascular Sciences and Research  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MANEESH K.","family":"RAI","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit, Department of Cardiology Sri Jayadeva Institute of Cardiovascular Sciences and Research  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAVIKUMAR KALYANI","family":"NAGASHETTY","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Sri Jayadeva Institute of Cardiovascular Sciences and Research  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GIRIDHAR","family":"KAMLAPURKAR","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Sri Jayadeva Institute of Cardiovascular Sciences and Research  Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.207"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.1o816.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89145-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.10.973"},{"key":"e_1_2_7_6_1","first-page":"575","article-title":"Left atrial ultrastructure in mitral valvular disease","volume":"89","author":"Thiedemann KU","year":"1977","journal-title":"Am J Pathol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.07.018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01182.x"},{"key":"e_1_2_7_9_1","first-page":"431","article-title":"Atrial fibrillation in pure rheumatic mitral valvular disease is expression of an atrial histological change","volume":"13","author":"Alessandri N","year":"2009","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12055-005-0062-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.029"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31827e180b"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1180"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.05.061"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2012.02341.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht194"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.02.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2013.12.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.9.3157"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.110284"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(01)00057-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80166-5"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.046"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.12.040"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1997.tb06199.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.183400"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00824-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.047"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2012.07.011"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.70"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.038"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2014.07.008"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.835"},{"issue":"1","key":"e_1_2_7_34_1","first-page":"S147","article-title":"Left atrial remodeling: Assessment of size and shape to detect vulnerability to atrial fibrillation","volume":"30","author":"Cozma D","year":"2007","journal-title":"Pacing Clin Electrophysiol"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.2.724"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13024","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T14:46:07Z","timestamp":1695739567000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/jce.13024"],"URL":"https:\/\/doi.org\/10.1111\/jce.13024","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}