{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:36:57Z","timestamp":1789097817200,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006279","name":"St. Jude Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Cryoballoon vs. Radiofrequency AF Ablation<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Radiofrequency (RF) and cryoballoon (CB) catheter ablation are effective for pulmonary vein isolation (PVI) in atrial fibrillation (AF). This report presents an updated meta\u2010analysis comparing the efficacy and safety of CB versus RF ablations in AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases and conference abstracts were systematically searched for studies that directly compared CB and RF PVI, and reported safety or efficacy outcomes in follow\u2010up \u226512 months. Recurrent atrial tachyarrhythmias (AT) were defined as AF, atrial flutter, or atrial tachycardia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two studies and 8,668 patients were included. Freedom from AT was not significantly different between CB and RF ablations in the pooled population (OR 1.12; 95%CI 0.97\u20131.29; P = 0.13) and in randomized trials (OR 1.0; 95%CI 0.65\u20131.56; P = 0.99). Second\u2010generation CB (CB2; 78.1%) and contact\u2010force (CF) sensing RF (78.2%) have improved procedure success rate as compared to first\u2010generation technology (57.9% CB, 58.1% RF). As compared to CF\u2010RF, CB2 demonstrated similar freedom from recurrent AT (OR 1.04; 95%CI 0.71\u20131.51; P = 0.84). The incidence of pericardial effusions (OR 0.44; 95%CI 0.28\u20130.69; P &lt; 0.01), tamponade (OR 0.31; 95%CI 0.15\u20130.64; P &lt; 0.01), and non\u2010AF AT (OR 0.46; 95%CI 0.26\u20130.83; P &lt; 0.01) were significantly lower with CB ablation, whereas transient phrenic nerve palsy was more incident after CB (OR 7.40; 95%CI 2.56\u201321.34; P &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was comparable freedom from AT between CB and RF in patients with AF undergoing PVI. Additionally, freedom from AT was similar between CB2 and CF\u2010RF. However, CB was associated with a lower incidence of pericardial effusions or tamponade, albeit with a higher rate of transient phrenic nerve palsies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13047","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T05:52:55Z","timestamp":1468648375000},"page":"1151-1159","source":"Crossref","is-referenced-by-count":93,"title":["Cryoballoon versus Radiofrequency Catheter Ablation in Atrial Fibrillation: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"RHANDERSON","family":"CARDOSO","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RODRIGO","family":"MENDIRICHAGA","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GILSON","family":"FERNANDES","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRIS","family":"HEALY","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LITSA K.","family":"LAMBRAKOS","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JUAN F.","family":"VILES\u2010GONZALEZ","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEFFREY J.","family":"GOLDBERGER","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAUL D.","family":"MITRANI","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine University of Miami, Jackson Memorial Hospital  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv323"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu376"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.859116"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.064"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu350"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.09.017"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.192419"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.12.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090323"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12695"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv419"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016871"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv060"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv271"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12582"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12846"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.12.016"},{"key":"e_1_2_6_21_1","unstructured":"WellsGA SheaB O'ConnellD PetersonJ WelchV LososM TugwellP: The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta\u2010analyses. 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