{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:25:36Z","timestamp":1778163936091,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T00:00:00Z","timestamp":1472515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Adenosine\u2010Guided Ablation of Atrial Fibrillation<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The prognostic significance of adenosine\u2010mediated pulmonary vein (PV) dormant conduction and whether such conduction should be eliminated still remain controversial. This randomized study aimed to investigate whether adenosine\u2010guided ablation of the reconnection gaps improves the long\u2010term outcomes of pulmonary vein antral isolation (PVAI) for paroxysmal atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Consecutive patients with paroxysmal AF were randomly assigned to undergo (n = 80, group 1) or not (n = 81, group 2) adenosine testing following PVAI. Adenosine\u2010mediated PV dormant conduction was unmasked in 26 patients (32.5%) of group 1. Successful elimination of the reconnection gaps was subsequently performed in all patients. During a mean follow\u2010up period of 11.39 \u00b1 5.10 months, 30 patients of group 1 (37.5%), and 27 patients of group 2 (33.3%) experienced arrhythmia recurrence. The Kaplan\u2013Meier arrhythmia free survival curves failed to demonstrate any significant differences between study groups (log rank 0.217, P = 0.642). Fourteen of 26 (53.8%) patients with adenosine\u2010mediated dormant conduction and subsequent elimination of reconnection gaps experienced AF recurrence during follow\u2010up. On the contrary, only 16 of 54 patients without dormant conduction (29.6%) displayed arrhythmia recurrence (P = 0.049). Logistic regression analysis showed that adenosine\u2010mediated PV reconnection (hazard ratio 0.292, 95% confidence interval 0.122\u20130.483; P = 0.01) was an independent predictor of AF recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this patients\u2019 cohort, adenosine\u2010mediated PV reconnection is predictive of future arrhythmic events. Elimination of dormant conduction with additional ablation lesions does not improve the long\u2010term outcome of the procedure compared to the standard PVAI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13059","type":"journal-article","created":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T16:09:10Z","timestamp":1470154150000},"page":"1288-1292","source":"Crossref","is-referenced-by-count":12,"title":["Adenosine\u2010Guided Pulmonary Vein Antral Isolation for Paroxysmal Atrial Fibrillation: A Randomized Study"],"prefix":"10.1111","volume":"27","author":[{"given":"MICHAEL","family":"EFREMIDIS","sequence":"first","affiliation":[{"name":"Second Department of Cardiology, Laboratory of Cardiac Electrophysiology \u201cEvangelismos\u201d General Hospital of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KONSTANTINOS P.","family":"LETSAS","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, Laboratory of Cardiac 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