{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:55:18Z","timestamp":1767084918196},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Cryoballoon Ablation of PAF<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The second\u2010generation cryoballoon (CB) has been recently introduced into clinical use for pulmonary vein isolation (PVI). Data on the feasibility, long\u2010term outcome, and optimal freeze cycle are still limited. We assessed the 1\u2010year clinical outcome after second\u2010generation CB ablation with single 3\u2010minute freeze techniques, and clinical variables associated with AF recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 108 paroxysmal atrial fibrillation (PAF) patients undergoing cryothermal PVI were enrolled. PVI was performed with one 28\u2010mm CB using single 3\u2010minute freeze techniques without bonus applications. Fourteen\u2010day consecutive monitoring was done after discharge to detect early AF recurrences (ERAFs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 425 PVs, 409 (96.2%) were isolated using exclusively CBs, and 16 required touch\u2010up ablation. Transient phrenic nerve injury, pericardial tamponade, and 50% PV stenosis occurred in 9, 1, and 1 patients, respectively. No PV stenosis &gt;50% was observed in any patients. The total procedure and fluoroscopic times were 82.9\u00a0\u00b1\u00a026.4 and 26.2\u00a0\u00b1\u00a014.8 minutes, respectively. ERAFs were detected in 51 (47.2%) patients. At 1\u2010year after single and repeat procedures, 71.6% and 84.3% of the patients were free from recurrent AF off antiarrhythmic drugs (AADs), respectively. Eighteen patients underwent repeat procedures (median 6.0 [4.0\u20139.3] months post procedure), and 68.6% of PVs were still isolated. Cox's proportional models determined that ERAFs were significantly associated with AF recurrence (HR = 7.236; 95%CI = 2.753\u201319.016; P &lt; 0.0001). AF\u2010freedom off AADs at 1\u2010year after single procedures was 90.8% and 50.3% in patients without and with ERAFs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Second\u2010generation CB ablation using single 3\u2010minute freeze techniques appears feasible in PAF patients. ERAFs were significant factors for predicting clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13078","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T07:44:02Z","timestamp":1471506242000},"page":"1375-1380","source":"Crossref","is-referenced-by-count":49,"title":["Pulmonary Vein Isolation Using a Second\u2010Generation Cryoballoon in Patients With Paroxysmal Atrial Fibrillation: One\u2010Year Outcome Using a Single Big\u2010Balloon 3\u2010Minute Freeze Technique"],"prefix":"10.1111","volume":"27","author":[{"given":"SHINSUKE","family":"MIYAZAKI","sequence":"first","affiliation":[{"name":"Cardiology Division, Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HITOSHI","family":"HACHIYA","sequence":"additional","affiliation":[{"name":"Cardiology Division, Cardiovascular Center Tsuchiura Kyodo Hospital  Tsuchiura Ibaraki 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