{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:53:07Z","timestamp":1789519987751,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Sex Differences in Inappropriate ICD Device Therapies<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Approximately 10\u201320% of ICD recipients receive inappropriate device therapies. The purpose of this study was to compare the frequency of inappropriate therapies (IT) between men and women enrolled in MADIT II and MADIT\u2010CRT, and assess for potential adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The electrograms for each ICD or CRT\u2010D therapy, defined as either ATP or shock, were reviewed by adjudication committees for both studies. ICD therapy was considered inappropriate if it was delivered for reasons other than VT\/VF. The rhythm triggering IT was categorized as atrial fibrillation\/flutter, SVT, or inappropriate sensing when possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand nine hundred and fifty\u2010four men and 556 women received ICD or CRT\u2010D devices. The risk of IT was significantly lower in women than men (9.2% vs. 13.5%, P = 0.006). The most common cause of IT in men was atrial fibrillation (38%) and SVT in women (43%). Inappropriate shock was not associated with increased mortality in either women (HR 0.82 [95% CI 0.11\u20136.08]; P = NS) or men (HR 1.37 [95% CI 0.75\u20132.48]; P = NS) by multivariate analysis. Conversely, appropriate shock therapy strongly correlated with increased risk of death during subsequent post\u2010shock follow\u2010up in women (HR 5.99 [95% CI 2.75\u201313.02]; P &lt; 0.0001) and men (HR 2.61 [95% CI 1.82\u20133.74]; P &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women experience significantly less IT than men, partially explained by the increased frequency of atrial fibrillation in men. IT was not associated with increased mortality in either sex. Appropriate shock therapy was a strong predictor of death in both, with women showing a 2\u2010fold higher risk than men during post\u2010shock long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13102","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T14:04:45Z","timestamp":1475849085000},"page":"94-102","source":"Crossref","is-referenced-by-count":9,"title":["Sex Differences in Inappropriate ICD Device Therapies: MADIT\u2010II and MADIT\u2010CRT"],"prefix":"10.1111","volume":"28","author":[{"given":"CHRISTINE M.","family":"TOMPKINS","sequence":"first","affiliation":[{"name":"Cardiology Division University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SCOTT","family":"MCNITT","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRONISLAVA","family":"POLONSKY","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES P.","family":"DAUBERT","sequence":"additional","affiliation":[{"name":"Cardiology Division Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAUL J.","family":"WANG","sequence":"additional","affiliation":[{"name":"Cardiology Division Stanford University of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ARTHUR J.","family":"MOSS","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WOJCIECH","family":"ZAREBA","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VALENTINA","family":"KUTYIFA","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010Up Program University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1933","article-title":"Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia","volume":"335","author":"Moss AJ","year":"1996","journal-title":"Multicenter Automatic Defibrillator Implantation Trial Investigators. 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