{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:12:21Z","timestamp":1785039141657,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Effect of PR Interval on CRT Outcomes<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prolonged PR intervals may impair atrioventricular mechanical coupling and adversely affect cardiac performance. We hypothesize that patients with advanced systolic heart failure, wide QRS complexes, and prolonged PR intervals will have improved survival from CRT\u2010D regardless of whether left bundle branch block (LBBB) or non\u2010LBBB is present.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A total of 308 patients enrolled in the optimal pharmacologic therapy (OPT) and 595 patients in the cardiac resynchronization therapy with defibrillation (CRT\u2010D) arms of the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure trial were stratified according to normal (\u2264230 ms) or prolonged PR interval (&gt;230 ms). The incidence of all\u2010cause mortality (ACM) or hospitalization (primary endpoint) and ACM (secondary endpoint) was compared using Kaplan\u2013Meier curves. Cox proportional hazards models for the primary and secondary endpoints were fit with LBBB status and baseline PR interval. CRT\u2010D treatment reduced both hospitalization\/ACM (P = 0.002) and ACM (P = 0.003) compared to OPT. However, CRT\u2010D was increasingly more effective in reducing ACM hazard in patients with longer baseline PR intervals (P = 0.002) regardless of LBBB status. In particular, in the prolonged baseline PR interval subgroup, ACM was reduced with CRT\u2010D compared to OPT (P = 0.001) with little evidence of ACM reduction in the normal PR subgroup (P = 0.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with advanced systolic heart failure, wide QRS complexes, and prolonged PR intervals, restoration of atrioventricular mechanical coupling with CRT\u2010D may improve survival regardless of LBBB status. In patients with non\u2010LBBB, a benefit from CRT\u2010D may occur with prolonged PR intervals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13131","type":"journal-article","created":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T07:02:41Z","timestamp":1480057361000},"page":"185-191","source":"Crossref","is-referenced-by-count":20,"title":["Effect of PR Interval on Outcomes Following Cardiac Resynchronization Therapy: A Secondary Analysis of the COMPANION Trial"],"prefix":"10.1111","volume":"28","author":[{"given":"JEFFREY","family":"LIN","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KEVIN A.","family":"BUHR","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics University of Wisconsin School of Medicine and Public Health  Madison Wisconsin 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