{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:03:23Z","timestamp":1768511003651,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>AV Node Innervation by the Right Vagus Nerve<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Radiofrequency isolation of pulmonary vein can be accompanied by transient sinus bradycardia or atrioventricular nodal (AVN) block, suggesting an influence on vagal cardiac innervation. However, the importance of the atrial fat pads in relation with the vagal innervation of AVN in humans remains largely unknown. The aim of this study was to evaluate the role of ganglionated plexi (GP) in the innervation of the AVN by the right vagus nerve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Direct epicardial high\u2010frequency stimulation (HFS) of the GP (20 patients) and the right vagus nerve (10 patients) was performed before and after fat pad exclusion or destruction in 20 patients undergoing thoracoscopic epicardial ablation for the treatment of persistent AF. Asystole longer than 3 seconds or acute R\u2010R prolongation over 25% was considered as a positive response to HFS. Prior to the ablation, positive responses to HFS were detected in 3 GPs in 7 patients (35%), 2 GPs in 5 patients (25%), and one GP in 8 patients (40%). After exclusion of the fat pads, all patients had a negative response to HFS. All the patients who exhibited a positive response to right vagus nerve stimulation (n = 10) demonstrated negative responses after the ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The integrity of the GP is essential for the right vagus nerve to exert physiological effects of on AVN in humans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13156","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T15:32:42Z","timestamp":1483025562000},"page":"432-437","source":"Crossref","is-referenced-by-count":7,"title":["Integrity of the Ganglionated Plexi Is Essential to Parasympathetic Innervation of the Atrioventricular Node by the Right Vagus Nerve"],"prefix":"10.1111","volume":"28","author":[{"given":"OLIVIER","family":"XHAET","sequence":"first","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, D\u00e9partement de m\u00e9decine, Service de cardiologie Unit\u00e9 de rythmologie  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUC","family":"DE ROY","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, D\u00e9partement de m\u00e9decine, Service de cardiologie Unit\u00e9 de rythmologie  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARIANA","family":"FLORIA","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, D\u00e9partement de m\u00e9decine, Service de cardiologie Unit\u00e9 de rythmologie  Yvoir Belgium"},{"name":"Grigore T. Popa University of Medicine and Pharmacy  Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLIVIER","family":"DECEUNINCK","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, D\u00e9partement de m\u00e9decine, Service de cardiologie Unit\u00e9 de rythmologie  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DOMINIQUE","family":"BLOMMAERT","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, D\u00e9partement de m\u00e9decine, Service de cardiologie Unit\u00e9 de rythmologie  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FABIEN","family":"DORMAL","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, D\u00e9partement de m\u00e9decine, Service de cardiologie Unit\u00e9 de rythmologie  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ELISABETH","family":"BALLANT","sequence":"additional","affiliation":[{"name":"Universit\u00e9 catholique de Louvain, CHU UCL Namur, D\u00e9partement de m\u00e9decine, Service de cardiologie Unit\u00e9 de rythmologie  Yvoir Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK","family":"LA MEIR","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel Centre for Cardiovascular Diseases  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.066"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.01.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4601.098517"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.03002.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.22.2237"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-005-2492-2"},{"key":"e_1_2_8_8_1","first-page":"335","article-title":"HRS\/EHRA\/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for personnel, policy, procedures and follow\u2010up. 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