{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:34:18Z","timestamp":1780724058826,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Early and Late Recurrences in AF Cryoablation<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recurrences within the blanking period (early recurrences) are common after atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI), but their clinical significance is still controversial. We aimed at evaluating the significance of within\u2010blanking recurrences at 12\u2010month follow\u2010up after cryoballoon (CB) PVI, and to assess the real procedural success rate by continuous monitoring of cardiac rhythm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Sixty consecutive AF patients (34 paroxysmal, 56.7%) underwent their first CB\u2010PVI at one Italian center (May 2013 to April 2015), and subsequent implantation of an implantable loop recorder (ILR). Overall, 12\u2010month success rate after the blanking period was 55%. The shortest detected event was 7 minutes long. Late recurrences were more frequent in non\u2010paroxysmal (19\/26, 73.1%) than in paroxysmal AF (8\/34, 23.5%; P &lt;0.001). Early recurrences occurred in 17 (28.3%) patients, with 14 also having late recurrences (82.3%), while only 13 out of 43 (30.2%) without within\u2010blanking recurrences experienced post\u2010blanking events (P &lt;0.001). Overall, early recurrences showed 51.8% sensitivity (95% CI 31.9\u201371.3%) and 90.9% specificity (95% CI 75.7\u201398.1%) for later recurrences, with 82.3% (95% CI 56.6\u201396.2%) positive and 69.8% (95% CI 53.9\u201382.8%) negative predictive value. The positive likelihood ratio was 5.7 (95% CI 1.8\u201317.8). At multivariable analysis, non\u2010paroxysmal AF (HR: 3.113; 95% CI 1.309\u20137.403; P = 0.010) and within\u2010blanking recurrences (HR: 3.453; 95% CI 1.544\u20137.722; P = 0.003) were independent predictors of post\u2010blanking AT\/AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CB\u2010PVI for paroxysmal AF shows a 12\u2010month success rate of 76.5% after one single procedure, as assessed by continuous cardiac rhythm monitoring. Within\u2010blanking recurrences predict the ablation failure in more than 80% of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13190","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T08:26:54Z","timestamp":1487320014000},"page":"625-633","source":"Crossref","is-referenced-by-count":28,"title":["Recurrences in the Blanking Period and 12\u2010Month Success Rate by Continuous Cardiac Monitoring After Cryoablation of Paroxysmal and Non\u2010Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"28","author":[{"given":"PAOLO","family":"PIERAGNOLI","sequence":"first","affiliation":[{"name":"Heart and Vessels Department University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALESSANDRO","family":"PAOLETTI PERINI","sequence":"additional","affiliation":[{"name":"Heart and Vessels Department University of Florence  Florence 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