{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:40:12Z","timestamp":1768783212845,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>ICD in Nonischemic Cardiomyopathy<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Implantation of an implantable cardioverter defibrillator (ICD) for primary prevention of sudden cardiac death (SCD) is controversial in view of the recent DANISH trial which suggested no benefit with ICD for primary prevention in patients with non\u2010ischemic cardiomyopathy (NICMP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a meta\u2010analysis of randomized control trials studying the role of ICD in primary prevention of SCD in patients with NICMP. Only six studies were identified after the application of inclusion\/exclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pooling of these randomized trials showed a statistically significant benefit of using ICDs in patients with NICMP [OR 0.76 (0.64 \u2013 0.91), I<jats:sup>2<\/jats:sup> = 0%]. Sensitivity analysis did not show a statistically significant mortality benefit of ICD in NICMP in trials which had adequate beta blocker, ACE\/ARB and aldosterone receptor blocker (ALD\u2010RB) use [OR 0.70 (0.41, 1.19), I<jats:sup>2<\/jats:sup> = 70%].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The DANISH trial's failure to show mortality benefit may be due to the significant number of patients who had CRT. Our meta\u2010analysis studied the independent effect of ICDs and showed them to be associated with net mortality benefits in patients who are not on optimal guideline directed medical therapy; especially the patients not on ALD\u2010RB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13192","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T22:30:55Z","timestamp":1490913055000},"page":"538-543","source":"Crossref","is-referenced-by-count":23,"title":["Mortality Effect of ICD in Primary Prevention of Nonischemic Cardiomyopathy: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"28","author":[{"given":"FARAZ KHAN","family":"LUNI","sequence":"first","affiliation":[{"name":"Mercy Saint Vincent Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HEMINDERMEET","family":"SINGH","sequence":"additional","affiliation":[{"name":"Mercy Saint Vincent Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ABDUR R.","family":"KHAN","sequence":"additional","affiliation":[{"name":"University of Louisville  Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SONIA A.","family":"MALIK","sequence":"additional","affiliation":[{"name":"Mercy Saint Vincent Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OWAIS","family":"KHAWAJA","sequence":"additional","affiliation":[{"name":"Mercy Saint Vincent Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HARIS","family":"RIAZ","sequence":"additional","affiliation":[{"name":"Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WADE","family":"LEE","sequence":"additional","affiliation":[{"name":"University of Toledo Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMEER","family":"KABOUR","sequence":"additional","affiliation":[{"name":"Mercy Saint Vincent Medical Center  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARK","family":"RICHARDS","sequence":"additional","affiliation":[{"name":"Toledo Hospital  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHAN","family":"AASBO","sequence":"additional","affiliation":[{"name":"Toledo Hospital  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_6_3_1","first-page":"e240","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"128","author":"WRITING COMMITTEE MEMBERS","year":"2013","journal-title":"Circulation"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl311"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.23.2874"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_6_10_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000012350.99718.AD"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033088"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608029"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00297-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409077"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.13.1389"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.03.049"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T08:53:49Z","timestamp":1695804829000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,30]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/jce.13192"],"URL":"https:\/\/doi.org\/10.1111\/jce.13192","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,30]]}}}