{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:06:29Z","timestamp":1769634389298,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010HL103812"],"award-info":[{"award-number":["R01\u2010HL103812"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Inappropriate implantable cardioverter\u2010defibrillator (ICD) shocks, commonly caused by atrial fibrillation (AF), are associated with an increased mortality. Because impaired left atrial (LA) function predicts development of AF, we hypothesized that impaired LA function predicts inappropriate shocks beyond a history of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We prospectively analyzed the association between LA function and incident inappropriate shocks in primary prevention ICD candidates. In the Prospective Observational Study of ICD (PROSE\u2010ICD), we assessed LA function using tissue\u2010tracking cardiac magnetic resonance (CMR) prior to ICD implantation. A total of 162 patients (113 males, age 56 \u00b1 15 years) were included. During the mean follow\u2010up of 4.0 \u00b1 2.9 years, 26 patients (16%) experienced inappropriate shocks due to AF (n = 19; 73%), supraventricular tachycardia (n = 5; 19%), and abnormal sensing (n = 2; 8%). In univariable analyses, inappropriate shocks were associated with AF history prior to ICD implantation, age below 70 years, QRS duration less than 120 milliseconds, larger LA minimum volume, lower LA stroke volume, lower LA emptying fraction, impaired LA maximum and preatrial contraction strains (S<jats:sub>max<\/jats:sub> and S<jats:sub>preA<\/jats:sub>), and impaired LA strain rate during left ventricular systole and atrial contraction (SR<jats:sub>s<\/jats:sub> and SR<jats:sub>a<\/jats:sub>). In multivariable analysis, impaired S<jats:sub>max<\/jats:sub> (hazard ratio [HR]: 0.96, P = 0.044), S<jats:sub>preA<\/jats:sub> (HR: 0.94, P = 0.030), and SR<jats:sub>a<\/jats:sub> (HR: 0.25, P &lt; 0.001) were independently associated with inappropriate shocks. The receiver\u2010operating characteristics curve showed that SR<jats:sub>a<\/jats:sub> improved the predictive value beyond the patient demographics including AF history (P = 0.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Impaired LA function assessed by tissue\u2010tracking CMR is an independent predictor of inappropriate shocks in primary prevention ICD candidates beyond AF history.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13234","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T07:54:40Z","timestamp":1492761280000},"page":"796-805","source":"Crossref","is-referenced-by-count":11,"title":["Impaired left atrial function predicts inappropriate shocks in primary prevention implantable cardioverter\u2010defibrillator candidates"],"prefix":"10.1111","volume":"28","author":[{"given":"Susumu","family":"Tao","sequence":"first","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-6892","authenticated-orcid":false,"given":"Hiroshi","family":"Ashikaga","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"},{"name":"Department of Biomedical Engineering Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa A.","family":"Ciuffo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihei","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao A.C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry F.","family":"Frank","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"},{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon F.","family":"Tomaselli","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Johns Hopkins University School of Medicine  MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1995.tb02603.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071098"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.115.002210"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen235"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer251"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004299"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.000083"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.04.015"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.968024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14131971"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0152-y"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001844"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.12.032"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2001.00016.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi580"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002769"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.463125"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer281"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.594531"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.007"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211107"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12273"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft053"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:19:44Z","timestamp":1696223984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/jce.13234"],"URL":"https:\/\/doi.org\/10.1111\/jce.13234","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]}}}