{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:39:18Z","timestamp":1754109558082,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ERA-NET PrioMedChild","award":["40-41800-98-026"],"award-info":[{"award-number":["40-41800-98-026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Case reports of life\u2010threatening cardiac arrhythmias and sudden cardiac arrest (SCA) among amphetamine users have raised serious concerns about the cardiac safety of this class of drugs. This is important in light of the high prevalence of dexamphetamine (dAMPH) prescription for attention\u2010deficit\/hyperactivity disorder (ADHD), and its rising use as a recreational drug. The objective was to investigate electrocardiogram (ECG) parameters upon intravenous administration of a single dAMPH dose in habitual recreational dAMPH users (users) and healthy gender\/age\/ intelligence\u2010quotient\u2010matched controls (non\u2010users).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>ECG recordings were made in 18 users and 18 non\u2010users during administration of dAMPH (0.3 mg\/kg body weight). Baseline ECG was normal in both groups. dAMPH elicited increased heart rate and corrected QT time (QTc) prolongation in both groups (all P &lt; 0.001, QTc = 502 in one individual). QTc prolongation was attenuated in users compared to non\u2010users, exhibiting a significant interaction effect (P = 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SCA associated with amphetamine use may be related to its QTc prolonging effects, particularly during first\u2010time use. These observations may provide a rationale for conducting ECG analysis immediately after the first\u2010time use of amphetamines, as this could potentially unmask vulnerable individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13235","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:22:21Z","timestamp":1493338941000},"page":"912-916","source":"Crossref","is-referenced-by-count":3,"title":["QT prolongation by dexamphetamine: Does experience matter?"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4035-4845","authenticated-orcid":false,"given":"Anouk","family":"Schrantee","sequence":"first","affiliation":[{"name":"Department of Radiology, Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"V\u00e1clav\u016f","sequence":"additional","affiliation":[{"name":"Department of Radiology, Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Reneman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein J.","family":"Verberne","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Booij","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanno L","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Academic Medical Center University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318250a870"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.05.034"},{"journal-title":"Drug Safety and Risk Management Advisory Committee Meeting","year":"2006","author":"Food and Drug Administration","key":"e_1_2_6_4_1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.09.001"},{"key":"e_1_2_6_6_1","article-title":"Lifetime prevalence of drug use by age and country (young adults (15\u201034))","author":"EMCDDA","year":"2015","journal-title":"Stat Bull"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1830"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110212"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.04.043"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9419-z"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022147"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003723"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01776.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.10.124"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2015.11.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.11.114"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:20:34Z","timestamp":1696285234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jce.13235"],"URL":"https:\/\/doi.org\/10.1111\/jce.13235","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"type":"print","value":"1045-3873"},{"type":"electronic","value":"1540-8167"}],"subject":[],"published":{"date-parts":[[2017,6,21]]}}}