{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:32:16Z","timestamp":1781047936063,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Abbott"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There remains controversy about the optimal ablation technique and termination rate of atrial fibrillation (AF) during catheter ablation in patients with persistent AF. The aim of this study was to determine the rate and timing of AF termination during combined pulmonary vein isolation (PVI) and focal impulse and rotor modulation (FIRM)\u2010guided ablation of rotational activity (RoAc).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, prospective cohort study enrolled 38 consecutive patients (63% male, mean age 63 \u00b1 11 years) with persistent AF (mean left atrial size: 46 \u00b1 7 mm), who underwent FIRM mapping and ablation of the identified RoAcs followed by PVI. We systematically evaluated the incidence and timing of AF termination during AF ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u201cLate\u2010onset termination\u201d of AF could be observed in 12 (32%) patients after ablation of the identified RoAcs. In a further 10 (26%) patients, \u201cabrupt\u201d AF termination during PVI was achieved. In total, the combined technique of conventional PVI and RoAc ablation resulted in AF termination rate of 58%. ECV was performed in 16 \u201cnonterminating\u201d patients. At 1\u2010year follow\u2010up, 76.1% (16 of 21) of patients remained free from AF\/AT, 4 of 10 patients (25%) within the \u201cabruptly\u201d terminated group, 7 of 12 (58.3%) patients among the \u201clate\u2010terminated\u201d group, and 5 of 16 (31, 25%) patients in the \u201cnonterminating\u201d group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Large area RoAc ablation combined with PVI results in a moderate termination rate of persistent AF with two distinctive timing patterns. More studies are needed to determine the clinical significance of type of AF termination and long\u2010term success rate of RoAc ablation in patients with persistent AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13240","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T09:06:45Z","timestamp":1493888805000},"page":"862-869","source":"Crossref","is-referenced-by-count":10,"title":["Type and rate of atrial fibrillation termination due to rotational activity ablation combined with pulmonary vein isolation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-6272","authenticated-orcid":false,"given":"Zsuzsanna","family":"Kis","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Erasmus MC University Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic A.","family":"Theuns","sequence":"additional","affiliation":[{"name":"Department of 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