{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:18:10Z","timestamp":1762507090376,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006279","name":"St. Jude Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006020","name":"Center for Translational Molecular Medicine","doi-asserted-by":"publisher","award":["01C\u2010203"],"award-info":[{"award-number":["01C\u2010203"]}],"id":[{"id":"10.13039\/501100006020","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Proper optimization of atrioventricular (AV) and interventricular (VV) intervals can improve the response to cardiac resynchronization therapy (CRT). It has been demonstrated that the area of the QRS complex (QRSarea) extracted from the vectorcardiogram can be used as a predictor of optimal CRT\u2010device settings. We explored the possibility of extracting vectors from the electrograms (EGMs) obtained from pacing electrodes and of using these EGM\u2010based vectors (EGMVs) to individually optimize acute hemodynamic CRT response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Biventricular pacing was performed in 13 dogs with left bundle branch block (LBBB) of which five also had myocardial infarction (MI), using 100 randomized AV\u2010 and VV\u2010settings. Settings providing an acute increase in LV dP\/dt<jats:sub>max<\/jats:sub> \u2265 90% of the highest achieved value were defined as optimal. The prediction capability of QRSarea derived from the EGMV (EGMV\u2010QRSarea) was compared with that of QRS duration. EGMV\u2010QRSarea strongly correlated to the change in LV dP\/dt<jats:sub>max<\/jats:sub> (R = \u22120.73 \u00b1 0.19 [LBBB] and \u22120.66 \u00b1 0.14 [LBBB + MI]), while QRS duration was more poorly related to LV dP\/dt<jats:sub>max<\/jats:sub> changes (R = \u22120.33 \u00b1 0.25 [LBBB] and \u22120.47 \u00b1 0.39 [LBBB + MI]). This resulted in a better prediction of optimal CRT\u2010device settings by EGMV\u2010QRSarea than by QRS duration (LBBB: AUC = 0.89 [0.86\u20130.93] vs. 0.76 [0.69\u20130.83], P &lt; 0.01; LBBB + MI: AUC = 0.91 [0.84\u20130.99] vs. 0.82 [0.59\u20131.00], P = 0.20, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In canine hearts with chronic LBBB with or without MI, the EGMV\u2010QRSarea predicts acute hemodynamic CRT response and identifies optimal AV and VV settings accurately. These data support the potency of EGM\u2010based vectors as a noninvasive, easy and patient\u2010tailored tool to optimize CRT\u2010device settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13241","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T18:02:41Z","timestamp":1493834561000},"page":"944-951","source":"Crossref","is-referenced-by-count":6,"title":["Prediction of optimal cardiac resynchronization by vectors extracted from electrograms in dyssynchronous canine hearts"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6300-0564","authenticated-orcid":false,"given":"Elien B.","family":"Engels","sequence":"first","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Strik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars B.","family":"van Middendorp","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Kuiper","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Vernooy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Cardiology Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits W.","family":"Prinzen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.097"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.23.2993"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9203-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00671.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.02.007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00770.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000753"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.966358"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-015-9615-7"},{"key":"e_1_2_6_14_1","article-title":"Local 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