{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T16:50:29Z","timestamp":1771692629175,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Brugada syndrome (BrS), it has been reported that delayed activation in the RV is related to the development of type\u20101 ECG, which is more critical than type\u20102. On the other hand, the coexistence of complete right bundle\u2010branch block (CRBBB), which also causes delayed activation in the RV, sometimes makes typical BrS ECG misleading. We hypothesized that premature stimulation of the RV can unmask the influence of delayed activation in the RV and convert the morphology of ECG in BrS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In 35 BrS patients with type\u20101 ECG including 8 patients with concomitant CRBBB and 6 control subjects with CRBBB, progressively premature single stimulations were delivered from the RV apex on electrophysiological study. Then we evaluated QRS morphology of fusion beats created by single premature stimulation in each patient. In 29 (83%) of 35 of the BrS patients, conversion from type\u20101 to type\u20102 ECG was observed during the process of single premature stimulation. Additionally, in all 8 BrS patients with concomitant CRBBB, type\u20101 or type\u20102 BrS ECG was revealed by premature stimulation with relief of CRBBB. These findings were not observed in any of the control subjects with CRBBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single premature stimulation of the RV converts ECG from type\u20101 to type\u20102 in most BrS cases and unmasks type\u20101 ECG in all BrS cases with CRBBB. Our results could suggest that type\u20101 ECG is associated with delayed activation of the RV compared with type\u20102 ECG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13336","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T11:05:38Z","timestamp":1504868738000},"page":"71-78","source":"Crossref","is-referenced-by-count":5,"title":["Impact of premature activation of the right ventricle with programmed stimulation in Brugada syndrome"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3591-9415","authenticated-orcid":false,"given":"Koji","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nagase","sequence":"additional","affiliation":[{"name":"Divisions of Arrhythmia and Electrophysiology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6419-1246","authenticated-orcid":false,"given":"Hiroshi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Cardiology Iwakuni Medical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masamichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences  Okayama 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