{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:57:07Z","timestamp":1783191427567,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Data on long\u2010term outcomes of cryoballoon (CB) ablation for treatment of persistent atrial fibrillation (AF) are sparse. Here, we report the first 3\u2010year follow\u2010up results and predictors of success for catheter ablation using the second\u2010generation CB in patients with persistent AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>For this prospective observational study, we enrolled 101 patients ablated with the second\u2010generation CB at our institution. The endpoint was the first documented recurrence (&gt;\u00a030\u00a0seconds) of AF, atrial flutter, or atrial tachycardia after a 3\u2010month blanking period. Follow\u2010up data were collected during outpatient clinic visits and included Holter\u2010ECG recordings. The impact of several variables on recurrence was evaluated by means of univariate and multivariate analyses and Cox proportional hazards regression models.<\/jats:p><jats:p>After a median follow\u2010up of 37 (31 of 42) months, recurrence was documented in 30 patients (29.7%). The median procedure and fluoroscopy times were 120 (102 of 147) and 20 (16 of 27) minutes, respectively. Phrenic nerve palsy occurred in 2.0% of the patients. Among the 30 patients who experienced recurrence, 16 underwent repeat ablation in radiofrequency technique. Cox regression analysis showed that left atrial area\u00a0&gt;\u00a021 cm<jats:sup>2<\/jats:sup> and AF history duration\u00a0&gt;\u00a02 years independently predicted recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sinus rhythm was maintained in a substantial proportion of patients even 3 years after CB ablation. Patients with a nonenlarged left atrium and short AF history had the best outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13372","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T11:52:34Z","timestamp":1508845954000},"page":"38-45","source":"Crossref","is-referenced-by-count":28,"title":["Second\u2010generation cryoballoon ablation for treatment of persistent atrial fibrillation: Three\u2010year outcome and predictors of recurrence after a single procedure"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2379-5443","authenticated-orcid":false,"given":"Ersan","family":"Akkaya","sequence":"first","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Berkowitsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergej","family":"Zaltsberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Greiss","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"},{"name":"Med. Clinic I Justus\u2010Liebig University  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Sperzel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kuniss","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.192419"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut417"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12409"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12417"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv092"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.09.063"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.002776"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.02.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography","volume":"18","author":"Lang RM","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"e_1_2_7_13_1","article-title":"Cryoballoon ablation of persistent atrial fibrillation: Feasibility and safety of left atrial roof ablation with generation of conduction block in addition to antral pulmonary vein isolation","volume":"146","author":"Kuniss M","year":"2016","journal-title":"Europace"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-012-9672-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu350"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12695"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-013-9855-x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12986"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-016-0987-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13193"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.03.050"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12157"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.054"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.10.009"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:42:57Z","timestamp":1694947377000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,10]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/jce.13372"],"URL":"https:\/\/doi.org\/10.1111\/jce.13372","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,10]]}}}