{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:19:43Z","timestamp":1769044783365,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"European Union Seventh Framework Programme","doi-asserted-by":"crossref","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is largely believed that atrial tachycardias (ATs) encountered during ablation of persistent atrial fibrillation (PsAF) are a byproduct of ablative lesions. We aimed to explore the alternative hypothesis that they may be a priori drivers of AF remaining masked until other AF sources are reduced or eliminated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Radiofrequency ablation of fibrillatory drivers mapped by electrocardiographic imaging (ECGI; ECVUE\u2122, Cardioinsight Technologies, Cleveland, OH, USA) terminated PsAF in 198 (73%) out of 270 patients (61 \u00b1 10 years, 9 \u00b1 9\u00a0m). Two hundred and six ATs in 158 patients were subsequently mapped. Their anatomic relationship to the fibrillatory drivers prospectively identified by ECGI was then established. There were 26 (13%), 52 (25%), and 128 (62%) focal, localized, and macrore\u2010entrant ATs, respectively. In focal\/localized re\u2010entrant ATs, 64 (82%) were terminated within an AF\u2010driver region, in which 26 (81%) among 32 focal\/localized ATs analyzed with 3\u2010D\u2010mapping system merged to driver map occurred from AF\u2010driver regions in 1.0 \u00b1 1.0\u00a0cm distance from the driver core. Importantly, there was no attempt at ablation of the associated AF\u2010driver region in 25 of 64 (39%) of focal\/localized re\u2010entrant ATs. The sites of ATs origin generally had low\u2010voltage, fractionated, and long\u2010duration electrograms in AF. All but two focal\/localized re\u2010entrant ATs were successfully ablated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of post\u2010AF\u2010ablation focal and localized re\u2010entrant ATs originate from the region of prospectively established AF\u2010driver regions. A third of these are localized to regions not subsequently submitted to ablation. These data suggest that many ATs exist, although not necessarily manifest independently, prior to ablation. They may have a role in the maintenance of PsAF in these individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13377","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T13:56:33Z","timestamp":1509026193000},"page":"274-283","source":"Crossref","is-referenced-by-count":15,"title":["Atrial tachycardias: Cause or effect with ablation of persistent atrial fibrillation?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5682-8937","authenticated-orcid":false,"given":"Seigo","family":"Yamashita","sequence":"first","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L'\u00e9v\u00eaque, Universit\u00e9 de Bordeaux LIRYC Institute: IHU LIRYC ANR\u201010\u2010IAHU\u201004 and Equipex MUSIC ANR\u201011\u2010EQPX\u20100030  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren A.","family":"Hooks","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L'\u00e9v\u00eaque, Universit\u00e9 de Bordeaux LIRYC Institute: IHU LIRYC ANR\u201010\u2010IAHU\u201004 and Equipex MUSIC ANR\u201011\u2010EQPX\u20100030  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Shah","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L'\u00e9v\u00eaque, Universit\u00e9 de Bordeaux LIRYC Institute: IHU LIRYC ANR\u201010\u2010IAHU\u201004 and Equipex MUSIC ANR\u201011\u2010EQPX\u20100030  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin","family":"Relan","sequence":"additional","affiliation":[{"name":"H\u00f4pital Cardiologique du Haut\u2010L'\u00e9v\u00eaque, Universit\u00e9 de Bordeaux LIRYC Institute: IHU LIRYC ANR\u201010\u2010IAHU\u201004 and Equipex MUSIC ANR\u201011\u2010EQPX\u20100030  Bordeaux 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