{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:09:41Z","timestamp":1788480581349,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study investigated the impact of weight loss in longstanding persistent (LSPAF) patients undergoing catheter ablation (CA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety consecutive obese LSPAF patients were approached; 58 volunteered to try weight loss interventions for up to 1\u00a0year (group 1), while 32 patients declined weight loss interventions and were included as a control (group 2). Both groups remained on antiarrhythmic drugs. If they continued to experience AF, CA was performed. Body weight was measured at 6\u2010month intervals and arrhythmia status was assessed by event recorder, electrocardiogram (ECG), and Holter monitoring. Symptom severity and quality of life (QoL) were evaluated by AFSS and SF\u201036 survey, respectively. A scoring algorithm with two summary measures, physical component score (PCS) and mental component score (MCS), was prepared for QoL analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant reduction in body weight (median \u221224.9 (IQR \u221219.1 to \u221256.7) kg, P\u00a0&lt;\u00a00.001) was observed in the group 1 patients, while no such change was seen in group 2. The PCS and MCS scores improved significantly in group 1 only, with a change from baseline of 8.4\u00a0\u00b1\u00a03 (P\u00a0=\u00a00.013) and 12.8\u00a0\u00b1\u00a08.2 (P\u00a0&lt;\u00a00.02). However, AF symptom severity remained unchanged from baseline in both groups (P\u00a0=\u00a00.84). All 90 patients eventually underwent CA and received PVAI+ posterior wall+ non\u2010PV triggers ablation. At 1\u2010year follow\u2010up after single procedure, 37 (63.8%) in group 1 and 19 (59.3%) patients in group 2 remained arrhythmia\u2010free off AAD (P\u00a0=\u00a00.68).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this prospective analysis, in LSPAF patients weight loss improved QoL but had no impact on symptom severity and long\u2010term ablation outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13394","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T07:46:47Z","timestamp":1511509607000},"page":"246-253","source":"Crossref","is-referenced-by-count":58,"title":["Impact of weight loss on ablation outcome in obese patients with longstanding persistent atrial fibrillation"],"prefix":"10.1111","volume":"29","author":[{"given":"Sanghamitra","family":"Mohanty","sequence":"first","affiliation":[{"name":"St. David's Medical Center Texas Cardiac Arrhythmia Institute  Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasant","family":"Mohanty","sequence":"additional","affiliation":[{"name":"St. David's Medical Center Texas Cardiac Arrhythmia Institute  Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Natale","sequence":"additional","affiliation":[{"name":"University of Texas at Austin  Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Trivedi","sequence":"additional","affiliation":[{"name":"St. David's Medical Center Texas Cardiac Arrhythmia Institute  Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Gianni","sequence":"additional","affiliation":[{"name":"St. David's Medical Center Texas Cardiac Arrhythmia Institute  Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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