{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T11:00:12Z","timestamp":1789729212424,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of overweight and obesity on outcomes in \u201creal world\u201d patients with atrial fibrillation (AF) is not fully defined. Second, sex differences in AF outcomes may also exist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      The aim was to investigate outcomes at 1 year follow\u2010up for AF patients enrolled in the EORP\u2010AF Registry, according to BMI (kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), comparing patients with normal BMI (18.5 to\u00a0&lt;\u00a025\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), overweight (25 to\u00a0&lt;\u00a030\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and obesity (\u2265 30\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), in relation to sex differences. Among 2,540 EORP AF patients (38.9% female; median age 69) with 1 year follow\u2010up data available, 720 (28.3%) had a normal BMI, 1,084 (42.7%) were overweight, and 736 (29.0%) were obese. Obese patients were younger and with more prevalent diabetes mellitus and hypertension (P\u00a0&lt;\u00a00. 001). One\u2010year outcomes showed that all\u2010cause mortality was significantly different according to BMI among female patients (9.3% normal BMI, 5.3% overweight, and 4.3 % obese, P\u00a0=\u00a00.023), but not among male patients (P\u00a0=\u00a00.748). The composite outcome of thromboembolic events and death was also significantly different, being lower in obese females (P\u00a0=\u00a00.035). Among male patients, bleeding events were significantly more frequent in obese subjects (P\u00a0=\u00a00.035). On multivariable Cox analysis, BMI was not independently associated with all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among AF patients, overweight and obesity are common and associated with better outcomes in females (a finding previously reported as \u201cobesity paradox\u201d), while no significant differences in outcomes are detected among male patients. Final multivariable model found that increasing BMI was not associated with increased risk of all\u2010cause death; conversely, age and comorbidities persisted as major determinants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.13428","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T07:00:27Z","timestamp":1516258827000},"page":"566-572","source":"Crossref","is-referenced-by-count":27,"title":["Overweight and obesity in patients with atrial fibrillation: Sex differences in 1\u2010year outcomes in the EORP\u2010AF General Pilot Registry"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4815","authenticated-orcid":false,"given":"Giuseppe","family":"Boriani","sequence":"first","affiliation":[{"name":"Cardiology Department University of Modena and Reggio Emilia, Policlinico di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Laroche","sequence":"additional","affiliation":[{"name":"EURObservational Research Programme Department European Society of Cardiology  Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Diemberger","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Department of Experimental, Diagnostic and Specialty Medicine University of Bologna, S. Orsola\u2010Malpighi University Hospital  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Fantecchi","sequence":"additional","affiliation":[{"name":"Cardiology Department University of Modena and Reggio Emilia, Policlinico di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Meeder","sequence":"additional","affiliation":[{"name":"Department of Cardiology VieCuri Medical Center  Venlo the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Kurpesa","sequence":"additional","affiliation":[{"name":"Cardiology Department Medica\u0142 University  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Mariana","family":"Baluta","sequence":"additional","affiliation":[{"name":"Cardiology Department Carol Davila University of Medicine and Pharmacy, St. Pantelimon Emergency Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Proietti","sequence":"additional","affiliation":[{"name":"University of Birmingham Centre for Cardiovascular Sciences, City Hospital  Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care&amp;Research. E.S. Health Science Foundation  Cotignola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo P.","family":"Maggioni","sequence":"additional","affiliation":[{"name":"EURObservational Research Programme Department European Society of Cardiology  Sophia Antipolis France"},{"name":"ANMCO Research Center  Firenze Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"University of Birmingham Centre for Cardiovascular Sciences, City Hospital  Birmingham United Kingdom"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the EORP\u2010AF General Pilot Registry Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31257-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026693"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.11.026"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.03.006"},{"key":"e_1_2_8_6_1","unstructured":"WHO Consultation on Obesity.World Health Organization. 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