{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:26:11Z","timestamp":1768818371274,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The PREVENT AF I study demonstrated that prophylactic pulmonary vein isolation (PVI) in patients with pure typical atrial flutter (AFL) resulted in substantial reduction of new\u2010onset atrial fibrillation (AF) during 1\u2010year follow\u2010up as assessed by continuous implantable cardiac monitor (ICM). The objective of this study was to assess 3\u2010year outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fifty patients with documented AFL were randomized to either cavotricuspid isthmus (CTI) ablation alone (n\u00a0=\u00a025) or CTI with concomitant PVI (n\u00a0=\u00a025). The primary endpoint of the study was the occurrence of any atrial tachyarrhythmia with the monthly burden exceeding 0.5% on the ICM. At the end of 3 years, freedom from any atrial tachyarrhythmia was 48% (95% confidence interval [CI]: 32\u201372%) in the CTI plus PVI group as compared to 20% (95% CI: 9\u201344%) in the CTI\u2010only group (P\u00a0=\u00a00.01). Freedom from redo procedures was also higher: 92% (95% CI: 82\u2013100%) versus 68% (95% CI: 52\u201389%), respectively (P\u00a0=\u00a00.027). The 3\u2010year AF burden favored the combined ablation group: 6.2%\u00a0versus 16.8% (P\u00a0=\u00a00.03). In the CTI\u2010only group, 12 (48%) patients were hospitalized compared to 4 (16%) in the PVI + CTI group (P\u00a0=\u00a00.03). Two patients in the CTI\u2010only group developed stroke with no serious adverse events in the PVI + CTI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic PVI in patients with only typical AFL resulted in a significant reduction of new\u2010onset AF and burden during long\u2010term follow\u2010up as assessed by ICM, with consequent reduction in hospitalizations and need to perform repeat ablation for AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13485","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T20:38:23Z","timestamp":1521837503000},"page":"872-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prophylactic pulmonary vein isolation during isthmus ablation for atrial flutter: Three\u2010year outcomes of the PREVENT AF I study"],"prefix":"10.1111","volume":"29","author":[{"given":"Alexander","family":"Romanov","sequence":"first","affiliation":[{"name":"E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian\u00a0Federation  Novosibirsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny","family":"Pokushalov","sequence":"additional","affiliation":[{"name":"E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian\u00a0Federation  Novosibirsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevda","family":"Bayramova","sequence":"additional","affiliation":[{"name":"E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian\u00a0Federation  Novosibirsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Ponomarev","sequence":"additional","affiliation":[{"name":"E. 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Meshalkin National Medical Research Center of the Ministry of Health of the Russian\u00a0Federation  Novosibirsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Elesin","sequence":"additional","affiliation":[{"name":"E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian\u00a0Federation  Novosibirsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Mikheenko","sequence":"additional","affiliation":[{"name":"E. Meshalkin National Medical Research Center of the Ministry of Health of the Russian\u00a0Federation  Novosibirsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-318X","authenticated-orcid":false,"given":"Jonathan S.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Heart Research Follow\u2010up Program University of Rochester School of Medicine &amp; Dentistry  Rochester NY USA"},{"name":"The SMG Arrhythmia Center Summit Medical Group  Short Hills NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00635-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2007.04.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.07.044"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00885.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01206.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.05.011"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01923.x"},{"key":"e_1_2_6_10_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2016"},{"key":"e_1_2_6_11_1","unstructured":"Stata\/IC 14.2 for Windows StataCorp LP USA."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12326"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht491"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"key":"e_1_2_6_15_1","first-page":"838","article-title":"Death and thrombo\u2010embolic risk after ablation of atrial flutter compared with atrial fibrillation: Nationwide cohort study","volume":"19","author":"Vadmann H","year":"2017","journal-title":"Europace"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-014-0682-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13122"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12688"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.02.018"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:44:56Z","timestamp":1695476696000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/jce.13485"],"URL":"https:\/\/doi.org\/10.1111\/jce.13485","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]},"assertion":[{"value":"2017-12-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}