{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:39:36Z","timestamp":1769348376046,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Experience with the subcutaneous implantable cardioverter\u2010defibrillator (S\u2010ICD) is expanding rapidly. However, data on long\u2010term performance or complications related to elective generator replacement are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Follow\u2010up (FU) data of all patients implanted between December 2008 and April 2011 were collected. Complications were defined as those requiring surgical intervention. Kaplan\u2010Meier estimates for complication and shock rates, with corresponding 95% confidence intervals (CI), were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eighteen patients were included. Median FU was 6.1 years (IQR 5.6\u20136.5 years). Short\u2010term complication rate (0\u201330 days) was 3% (CI 0\u20136%). Long\u2010term complication rate at 6 years was 19% (CI 12\u201326%), corresponding with an annual complication rate of 3%. One patient in this cohort developed a need for a transvenous ICD (TV\u2010ICD) in order to provide pacing for bradycardia (1%). Six patients were implanted with a TV\u2010ICD after experiencing an S\u2010ICD complication for which extraction was necessary. In total, 10 S\u2010ICDs were extracted; none resulted in a complication. Eight patients had a nonsystemic ICD\u2010related infection and no lead failures were observed. The majority, 68 (58%) patients, received an elective generator replacement. Two patients had a complication related to generator replacement (3%). Battery longevity was 5.6 years (IQR 5.2\u20136.1). Appropriate and inappropriate shock rates of 6\u2010year estimates were 17% (CI 9\u201325%) and 21% (CI 15\u201327%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This cohort represents the longest follow\u2010up to date and shows a low annual complication rate without lead failures or systemic infections. Battery longevity of the first S\u2010ICD generation results in relative early generator replacement procedures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13498","type":"journal-article","created":{"date-parts":[[2018,4,7]],"date-time":"2018-04-07T02:25:14Z","timestamp":1523067914000},"page":"1010-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Six\u2010year follow\u2010up of the initial Dutch subcutaneous implantable cardioverter\u2010defibrillator cohort: Long\u2010term complications, replacements, and battery longevity"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-984X","authenticated-orcid":false,"given":"Anne\u2010Floor B. E.","family":"Quast","sequence":"first","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-1518","authenticated-orcid":false,"given":"Vincent F.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sing\u2010Chien","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander H.","family":"Maass","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas V. A.","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology St Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-9700","authenticated-orcid":false,"given":"Dominic A.","family":"Theuns","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinoud E.","family":"Knops","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909545"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.047"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.040"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003042"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0396"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.053"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.044"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.017"},{"key":"e_1_2_6_10_1","unstructured":"FDA.SUMMARY OF SAFETY AND EFFECTIVENESS DATAhttps:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf11\/P110042b.pdf: FDA;2012. 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