{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:33:01Z","timestamp":1773945181942,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670309"],"award-info":[{"award-number":["81670309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>To assess the predictors of hemoptysis using second\u2010generation cryoballoon (CB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with hemoptysis after second\u2010generation CB ablation and 60 age\u2010, gender\u2010, and body mass index\u2010matched controls were recruited. Anatomic parameters were obtained from preprocedural cardiac computed tomography (CT). Pulmonary vein isolation was performed with 28\u2010mm balloon using single 3\u2010minute freeze technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical and procedural characteristics were similar between the groups. A shorter distance between left superior PV (LSPV) and left main bronchus (LMB) was associated with hemoptysis (7.8\u00a0\u00b1\u00a04.3\u00a0mm vs. 12.5\u00a0\u00b1\u00a03.5\u00a0mm, P\u00a0&lt;\u00a00.001), whereas no significant difference in the distance between right superior PV (RSPV) and right main bronchus (RMB) was found between groups (11.9\u00a0\u00b1\u00a03.5\u00a0mm vs. 12.9\u00a0\u00b1\u00a04.6\u00a0mm, P\u00a0=\u00a00.089). Additionally, the mean thickness of the connective tissue interposed between RSPV and RMB was significantly thicker than that between LSPV and LMB in both groups (both P\u00a0&lt;\u00a00.001). A stepwise logistic multivariate analysis identified only the LMB\u2010LSPV distance as an independent predictor of hemoptysis (odd ratio [OR] 2.676; 95% CI 1.121\u20134.843, P\u00a0&lt;\u00a00.001). A cutoff value \u2264 9.5\u00a0mm predicted hemoptysis after CB ablation with 93.8% sensitivity and 75.0% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hemoptysis is a relatively rare event following second\u2010generation CB ablation. The bronchi location obtained from CT aids in identifying high\u2010risk population for the complication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13644","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T13:07:41Z","timestamp":1527944861000},"page":"958-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of hemoptysis in the setting of pulmonary vein isolation using the second\u2010generation cryoballoon"],"prefix":"10.1111","volume":"29","author":[{"given":"Hui\u2010Qiang","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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