{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:46:11Z","timestamp":1790199971192,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n PV reconnection is often the result of catheter instability and tissue edema. High\u2010power short\u2010duration (HP\u2010SD) ablation strategies have been shown to improve atrial linear continuity in acute pre\u2010clinical models. This study compares the safety, efficacy, and long\u2010term durability of HP\u2010SD ablation with conventional ablation.<\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n In 6 swine, 2 ablation lines were performed anterior and posterior to the crista terminalis, in the smooth and trabeculated right atrium, respectively; and the right superior PV was isolated. In 3 swine, ablation was performed using conventional parameters (Thermocool\u2010Smarttouch\n \u00ae<\/jats:sup>\n SF; 30 W\/30\u00a0seconds) and in 3 other swine using HP\u2010SD parameters (QDOT\u2010MICRO\u2122, 90 W\/4\u00a0seconds). After 30 days, linear integrity was examined by voltage mapping and pacing, and the heart and surrounding tissues were examined by histopathology. Acute line integrity was achieved with both ablation strategies; however, HP\u2010SD ablation required 80% less RF time compared with conventional ablation (P\u00a0\u2264\u00a00.01 for all lines). Chronic line integrity was higher with HP\u2010SD ablation: all 3 posterior lines were continuous and transmural compared to only 1 line created by conventional ablation. In the trabeculated tissue, HP\u2010SD ablation lesions were wider and of similar depth with 1 of 3 lines being continuous compared to 0 of 3 using conventional ablation. Chronic PVI without stenosis was evident in both groups. There were no steam\u2010pops. Pleural markings were present in both strategies, but parenchymal lung injury was only evident with conventional ablation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n HP\u2010SD ablation strategy results in improved linear continuity, shorter ablation time, and a safety profile comparable to conventional ablation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jce.13651","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T09:07:08Z","timestamp":1527671228000},"page":"1287-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":144,"title":["High\u2010power and short\u2010duration ablation for pulmonary vein isolation: Safety, efficacy, and long\u2010term durability"],"prefix":"10.1111","volume":"29","author":[{"given":"Michael","family":"Barkagan","sequence":"first","affiliation":[{"name":"Harvard\u2010Thorndike Electrophysiology Institute, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando M.","family":"Contreras\u2010Valdes","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Electrophysiology Institute, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Leshem","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Electrophysiology Institute, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred E.","family":"Buxton","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Electrophysiology Institute, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Research Institute University of Oklahoma Health Sciences Center Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8199-2288","authenticated-orcid":false,"given":"Elad","family":"Anter","sequence":"additional","affiliation":[{"name":"Harvard\u2010Thorndike Electrophysiology Institute, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv057"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.07.033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-013-9864-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.02.022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.035"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.11.018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00269099"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.10.016"}],"container-title":["Journal of Cardiovascular 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