{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:02:52Z","timestamp":1762999372227,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Data on inappropriate and appropriate ICD therapy, and efficacy of ICD programing strategies by race are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In MADIT\u2010RIT, we evaluated the risk of ICD therapy by race, and the efficacy of high rate cut\u2010off ventricular tachycardia (VT) zone \u2265200 beats per minute (bpm) (Arm B), or 60 seconds delay in VT zone 170\u2013199\u00a0bpm (Arm C), compared to 2.5 seconds delay at 170\u00a0bpm (Arm A) among black and white patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MADIT\u2010RIT enrolled 272 (20%) black and 1119 (80%) white patients. The risk of inappropriate therapy was similar among blacks and whites, HR 1.25, 95% CI (0.82\u20131.93), <jats:italic>P\u00a0\u00a0=\u00a0\u00a0<\/jats:italic>0.30. High rate cut\u2010off or delayed VT therapy was associated with significant reductions in inappropriate therapy among whites, Arm B versus Arm A, HR 0.15, 95% CI (0.08\u20130.29), <jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.0001, Arm C versus Arm A, HR 0.19, 95% CI (0.11\u20130.33), <jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.001, and black individuals Arm B versus Arm A, HR 0.24, 95% CI (0.01\u20130.56), <jats:italic>P\u00a0\u00a0<\/jats:italic>=\u00a0\u00a00.0001, Arm C versus Arm A, HR 0.30, 95% CI (0.13\u20130.68), <jats:italic>P\u00a0\u00a0=\u00a0\u00a0<\/jats:italic>0.004, <jats:italic>P<\/jats:italic> interaction<jats:italic>\u00a0&gt;<\/jats:italic>\u00a00.10). However, delayed VT therapy was associated with a trend toward greater reduction in appropriate therapy in black individuals, HR 0.08, 95% CI (0.03\u20130.27), <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001 relative to white individuals, HR 0.27, 95% CI (0.16\u20130.43), <jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.0001, <jats:italic>P<\/jats:italic> interaction<jats:italic>\u00a0\u00a0<\/jats:italic>=\u00a0\u00a00.077.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In MADIT\u2010RIT, high rate and delayed detection ICD programming provided similar benefit with reductions in both inappropriate therapy and unnecessary appropriate therapy among black and white individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinicaltrials.gov identifier<\/jats:title><jats:p>NCT00947310<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13693","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T10:10:04Z","timestamp":1530871804000},"page":"1418-1424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of high rate and delayed detection ICD programming by race: A MADIT\u2010RIT substudy"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0195-1081","authenticated-orcid":false,"suffix":"II","given":"Larry R.","family":"Jackson","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute Duke University Medical Center  Durham North 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