{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T22:55:38Z","timestamp":1780872938793,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> The utilization of cardiac resynchronization therapy defibrillator (CRT\u2010D) has increased significantly, since its initial approval for use in selected patients with heart failure. Limited data\u00a0exist as for current trends in implant\u2010related in\u2010hospital complications and cost utilization. The aim of our study was to examine in\u2010hospital complication rates associated with CRT\u2010D and their trends over the last decade.<\/jats:p><jats:p><jats:bold>Methods and Results:<\/jats:bold> Using the Nationwide Inpatient Sample, we estimated 378\u2009248 CRT\u2010D procedures from 2003 to 2012. We investigated common complications, including mechanical, cardiovascular, pericardial complications (hemopericardium, cardiac tamponade, or pericardiocentesis), pneumothorax, stroke, vascular complications (consisting of hemorrhage\/hematoma, incidents requiring surgical repair, and accidental arterial puncture), and in\u2010hospital deaths described with CRT\u2010D, defining them by the validated International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code. Mechanical complications (5.9%) were the commonest, followed by cardiovascular (3.6%), respiratory failure (2.4%), and pneumothorax (1.5%). Age (\u226565 years), female gender (OR, 95% CI; <jats:italic>P<\/jats:italic> value) (1.08, 1.03\u20101.13; 0.001), and the Charlson score \u22653 (1.52, 1.45\u20101.60; &lt;0.001) were significantly associated with increased mortality\/complications.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The overall complication rate in patients undergoing CRT\u2010D has been increasing in the last decade. Age (\u226565), female sex, and the Charlson score \u22653 were associated with higher complications. In patients who underwent CRT\u2010D implantation, postoperative complications were associated with significant increases in cost.<\/jats:p>","DOI":"10.1111\/jce.13701","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T13:46:37Z","timestamp":1531835197000},"page":"1425-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Frequency of in\u2010hospital adverse outcomes and cost utilization associated with cardiac resynchronization therapy defibrillator implantation in the United States"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-1922","authenticated-orcid":false,"given":"Nilay","family":"Patel","sequence":"first","affiliation":[{"name":"Internal Medicine Department Saint Peter s University Hospital New Brunswick New 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