{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:45:48Z","timestamp":1771515948634,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The single\u2010chamber implantable cardioverter\u2010defibrillator (ICD) can be associated with more frequent inappropriate therapies compared with dual\u2010chamber ICDs, when\u00a0they are accompanied by a simpler implantation procedure. The aim of this study was to investigate whether the use of a single\u2010lead ICD system with atrial\u2010sensing electrodes results in a reduction of inappropriate ICD therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The study population consisted of 212 consecutive patients, who underwent primary prophylactic single\u2010lead ICD implantation at our institute. A ventricular lead with atrial\u2010sensing electrodes was implanted in 77 patients (36%; Group\u2010VDD) and a ventricular lead without atrial\u2010sensing electrodes was implanted in 135 patients (64%; Group\u2010VVI). Procedural and follow\u2010up data were collected in a prospective registry. A higher prevalence of atrial fibrillation was present in Group\u2010VDD. There were no other significant differences in patient baseline characteristics (age, sex, and other comorbidities) or follow\u2010up period between the two groups. The operative parameters including fluoroscopic burden showed no significant differences between Group\u2010VDD and Group\u2010VVI. During a mean follow\u2010up period of 697\u2009\u00b1\u2009392 days, 26 patients (12%) experienced appropriate ICD therapies and 13 patients (6%) suffered inappropriate ICD therapies. The incidence of inappropriate ICD therapies in Group\u2010VDD was significantly lower as compared to that of Group\u2010VVI (1\/77 [1%] vs 12\/135 [9%]; log\u2010rank, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.028). The incidence of appropriate ICD therapies and the occurrence of device\u2010related complications showed no significant difference between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single\u2010lead ICD with atrial\u2010sensing electrodes shows a lower incidence of inappropriate ICD therapy compared with the absence of atrial\u2010sensing electrodes, without additional operative burden or increased complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13736","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T08:11:32Z","timestamp":1536653492000},"page":"1682-1689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Avoiding inappropriate therapy of single\u2010lead implantable cardioverter\u2010defibrillator by using atrial\u2010sensing electrodes"],"prefix":"10.1111","volume":"29","author":[{"given":"Muhammed","family":"Kurt","sequence":"first","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikesh","family":"Jathanna","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Babady","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shqipe","family":"Gerguri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Clasen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Bejinariu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of the Heinrich Heine University D\u00fcsseldorf D\u00fcsseldorf Germany"},{"name":"Cardiovascular Research Institute Duesseldorf (CARID), Medical Faculty of the Heinrich Heine University 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