{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:27:23Z","timestamp":1791239243166,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Automated algorithms may identify focal (FA) and rotational (RoA) activations during persistent atrial fibrillation (PeAF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate an automated algorithm for characterizing and assessing significance of FA\/RoA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty\u2010six PeAF ablation patients (1411 maps) were analyzed. Maps were obtained with a 64\u2010electrode basket using CARTOFINDER, which filters\/annotates atrial unipolar electrograms over 30\u2009seconds. Operators ablated FA\/RoA followed by pulmonary vein isolation (PVI). The automated algorithm was retrospectively applied using QS patterns to identify FA and sequential activation gradients for RoA without phase mapping. Algorithm\u2010identified FA and RoA were validated against blinded adjudicators. Ablation of algorithm\u2010identified FA\/RoA was related to procedural AF termination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      73%\u2009\u00b1\u200918% of electrodes (65%\u2009\u00b1\u200911% atrial surface area) were adequate for analysis. Compared with adjudicators, the algorithm had a sensitivity of 84% for FA and 86% for RoA. There were 4\u2009\u00b1\u20092 FA and 2\u2009\u00b1\u20092 RoA per patient. FA occurred 8\u2009\u00b1\u20096 times during the 30\u2010second window (cumulative duration 8\u2009\u00b1\u20096\u2009seconds). RoA occurred 5\u2009\u00b1\u20093 times (median 2, consecutive rotations) with a cumulative duration of 3\u2009\u00b1\u20092\u2009seconds. Compared to patients without procedural AF termination, patients with termination had more FA ablated (75% vs 38%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006). AF termination was not predicted by percentage of RoA ablated although there was a trend towards a higher percentage of left atrial RoA ablated (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An automated algorithm had high sensitivity for FA and RoA. Acute AF termination was associated with FA ablation but not RoA ablation. Future studies need to define the significance of FA and RoA and whether they are overlapping or separate mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.13742","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T06:48:53Z","timestamp":1537339733000},"page":"1480-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Characterization and significance of localized sources identified by a novel automated algorithm during mapping of human persistent atrial fibrillation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-9727","authenticated-orcid":false,"given":"Atul","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Cardiology, Southlake Regional Health Center, University of Toronto  Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, OLVZ Aalst Antwerpen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Skanes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, London Health Sciences Center London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Duytschaever","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint\u2010Jan Hospital Bruges Bruges Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Bulava","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of South Bohemia Ceske Budejovice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Urman","sequence":"additional","affiliation":[{"name":"Haifa Technology Center, Biosense Webster Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yariv A.","family":"Amos","sequence":"additional","affiliation":[{"name":"Haifa Technology Center, Biosense Webster Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom de","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, OLV Hospital Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408288"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004398"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.014"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.022"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.09.177"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw168"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.853804"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.543"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.002721"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13132"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.01.003"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.08.001"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005922"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.04.043"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.37"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.12.033"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005274"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv233"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005258"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.13742","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:40:15Z","timestamp":1694313615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/jce.13742"],"URL":"https:\/\/doi.org\/10.1111\/jce.13742","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,8]]},"assertion":[{"value":"2018-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}