{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T15:32:50Z","timestamp":1775489570211,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670309"],"award-info":[{"award-number":["81670309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The procedural findings and clinical outcome of second\u2010generation cryoballoon (CB2) ablation in patients with variant pulmonary vein (PV) anatomy have not been fully investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 424 consecutive patients who underwent PV isolation with CB2 were included. Computed tomographic (CT) scan was performed in all patients before the procedure. The study population was divided into common PV, accessory PV, and nonvariant PV groups according to the CT scan. Procedural findings and clinical outcome between the three groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Variant PV anatomy was observed in 118 of 424 (27.8%) patients. PV isolation was successfully achieved in all patients in three groups with low rates of need for touch\u2010up ablation (<jats:italic>P<\/jats:italic>\u2009=\u20090.974). Total procedure time was longer in the accessory PV group compared with nonvariant PV group (53.7\u2009\u00b1\u200912.9 vs 49.5\u2009\u00b1\u20098.8\u2009minutes; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). More number of applications per patient were required in accessory PV group compared with the nonvariant PV and common PV groups (7.5\u2009\u00b1\u20092.1 vs 6.5\u2009\u00b1\u20091.6, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; 7.5\u2009\u00b1\u20092.1 vs 6.8\u2009\u00b1\u20091.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.027, respectively). No significant difference in phrenic nerve (PN) injury was observed between the three groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.693). During mean follow\u2010up duration of 16.1\u2009\u00b1\u20093.3 months, there was no significant difference in rates of atrial fibrillation (AF) recurrences in the three groups (13 of 43 common PV group, 21 of 75 accessory PV group, and 80 of 306 nonvariant PV group, <jats:italic>P<\/jats:italic>\u2009=\u20090.178).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variant PV patterns are common in patients undergoing ablation for drug\u2010resistant AF. CB2 ablation appears to be a reasonable strategy in the setting of the variant PV anatomy with a small increase in procedure time and the number of cryoapplications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13768","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T03:45:01Z","timestamp":1538797501000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Procedural findings and clinical outcome of second\u2010generation cryoballoon ablation in patients with variant pulmonary vein anatomy"],"prefix":"10.1111","volume":"30","author":[{"given":"Hui\u2010Qiang","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Gang","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong\u2010Bu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University Third Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-3774","authenticated-orcid":false,"given":"Jian\u2010Du","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Yang","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Cardiovascular Division Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 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