{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:27:31Z","timestamp":1773296851422,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Both isoproterenol (Iso) and adenosine (Ado) are used to induce atrial fibrillation (AF) in the electrophysiology lab. However, the utility of Ado has not been systematically established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to compare Ado to Iso for the induction of paroxysmal AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients (16 women; mean age, 60\u2009\u00b1\u200912 years) with paroxysmal AF, presenting for ablation were prospectively included of whom 36 (90%) received Ado (18\u201036\u2009mg) and\/or Iso (3\u201020\u2009\u00b5g\/min incremental dose) in a randomized order (26 [72%] received both drugs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AF was induced with Iso in 15 of 32 (47%) and with Ado in 12 of 30 (40%) patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.9). Iso\u2010triggered AF started from the left pulmonary veins (PVs) in 11 of 15 (73%), from the right PVs in 3 of 15 (20%), and from the coronary sinus (CS) in 1 of 15 (7%) cases. Ado\u2010induced AF episodes originated from the left PVs in 6 of 12 (50%), from the right atrium (RA) in 4 of 12 (33%), and from the CS in 2 of 12 (17%) cases. Altogether, Iso\u2010induced AF was more likely initiated from the PVs (93%) compared with Ado (50%) (\n<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Ado\u2010induced non\u2010PV triggers were not predictive of arrhythmia recurrence after PV isolation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ado much more frequently induces non\u2010PV triggers, especially from the RA. The clinical significance of these foci, however, is questionable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13779","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T10:25:02Z","timestamp":1540895102000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Is adenosine useful for the identification of atrial fibrillation triggers?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-9584","authenticated-orcid":false,"given":"Cristina","family":"Tutuianu","sequence":"first","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre, University of Szeged Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pap","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre, University of Szeged Szeged 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