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This study was to investigate the possible underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dogs were randomly divided into the sham\u2010operated group (SO; n\u2009=\u20096), AMI group (AMI; n\u2009=\u20098) and the group undergoing LOM<jats:sub>LSPV<\/jats:sub> ablation ahead of AMI (LOMD+AMI; n\u2009=\u20098). Incidence of VAs, serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD), expression of connexin (Cx43), Bcl\u20102, Bax, caspase\u20103, tumor necrosis factor (TNF)\u2010\u03b1, interleukin\u20106 (IL\u20106), and high mobility group box (HMGB)1 were compared. Anatomic and immunostaining examinations of LOM\n<jats:sub>LSPV<\/jats:sub> were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the AMI group, incidence of VAs was reduced in the LOMD+AMI group. Compared with the SO group, Cx43, SOD, and Bcl\u20102 were decreased, MDA, Bax, caspase\u20103, TNF\u2010\u03b1, IL\u20106, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group. A visual nerve fiber communication between the left stellate ganglion (LSG) and LOM and abundant sympathetic nerve bundles distribution in LOM<jats:sub>LSPV<\/jats:sub> were revealed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LOM<jats:sub>LSPV<\/jats:sub> ablation could suppress VAs during AMI. The possible mechanism may be associated with disconnection of the sympathetic conduit from LSG to the ventricles. Preservation of Cx43, inhibition of cardiac oxidative stress, apoptosis, and inflammation may be involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13802","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T10:33:41Z","timestamp":1544006021000},"page":"374-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Selective ablation of ligament of Marshall inhibits ventricular arrhythmias during acute myocardial infarction: Possible mechanisms"],"prefix":"10.1111","volume":"30","author":[{"given":"Xiaomei","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan China"},{"name":"Cardiovascular Research Institute, Wuhan University Wuhan China"},{"name":"Hubei Key Laboratory of Cardiology Wuhan 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