{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:41:50Z","timestamp":1772548910804,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pulmonary vein isolation (PVI) is the cornerstone ablation strategy for treatment of atrial fibrillation (AF). Ablation outside the PVs is sometimes needed particularly in persistent or longstanding AF. This study reported left atrial appendage isolation (LAAI) using cryoballoon (CB) focusing on technical data and short\u2010term clinical follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Patients with recurrent persistent AF after multiple AF procedures were enrolled. LAAI was performed using the second generation CB guided by compound motor action potential (CMAP) and 240\u2009seconds plus bonus freeze (ICE\u2010B) protocol. Ten patients were included, median age was 69.5 (56\u201073) years, CHA<jats:sub>2<\/jats:sub>DS\n<jats:sub>2<\/jats:sub>\u2010VASc score was 3 (1.8\u20104), LA diameter was 44 (38.8\u201046.5)\u2009mm. All patients had a mean of three AF procedures before the LAAI procedure. All patients were under successful CMAP guidance. During the CB LAAI procedure, the median time to LAA isolation was 100 (76\u2010270)\u2009seconds, minimal freeze temperature was \u221250 (\u221257 to \u221247)\u00b0C. A \u201cpull\u2010down (or pull\u2010away)\u201d CB maneuver was performed in all patients. Median fluoroscopic time was 4.8 (3.4\u20106.8)\u2009minutes and acute LAAI success rate was 100%. No phrenic nerve injury or other major complications were observed. At 6\u2010week follow\u2010up, remapping of the LAA showed durable isolation of all PVs (100%), all patients were scheduled for LAA occlusion. Six\u2010month follow\u2010up showed that 80% of patients were free from AF\/AT recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CMAP plus ICE\u2010B guided LAAI using cryo\u2010technology appears feasible and safe, results in durable LAAI, and shows promising clinical results in patients with recurrent persistent AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13818","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T16:07:51Z","timestamp":1545408471000},"page":"272-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Compound motor action potential guided 240\u2009seconds plus bonus freeze for safe and durable left atrial appendage isolation in patients with recurrent persistent atrial fibrillation: How to isolate the appendage with cryoballoon (the CMAP guided ICE\u2010B protocol)"],"prefix":"10.1111","volume":"30","author":[{"given":"Shaojie","family":"Chen","sequence":"first","affiliation":[{"name":"Frankfurt Academy For Arrhythmias (FAFA), Cardioangiologisches Centrum Bethanien (CCB), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Frankfurt Academy For Arrhythmias (FAFA), Cardioangiologisches Centrum Bethanien (CCB), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bordignon","sequence":"additional","affiliation":[{"name":"Frankfurt Academy For Arrhythmias (FAFA), Cardioangiologisches Centrum Bethanien (CCB), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Frankfurt Academy For Arrhythmias (FAFA), Cardioangiologisches Centrum Bethanien (CCB), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Bologna","sequence":"additional","affiliation":[{"name":"Frankfurt Academy For Arrhythmias (FAFA), Cardioangiologisches Centrum Bethanien (CCB), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Nagase","sequence":"additional","affiliation":[{"name":"Frankfurt Academy For Arrhythmias (FAFA), Cardioangiologisches Centrum Bethanien (CCB), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. R. Julian","family":"Chun","sequence":"additional","affiliation":[{"name":"Frankfurt Academy For Arrhythmias (FAFA), Cardioangiologisches Centrum Bethanien (CCB), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,6]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu376"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309781"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005250"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.07.007"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux372"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.11.009"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602014"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux005"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.002885"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu320"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13201"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn570"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13607"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.02.033"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.014"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13276"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.11.009"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.07.002"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.001238"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.12.014"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2018;1;2"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.13818","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:24:14Z","timestamp":1694719454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,6]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/jce.13818"],"URL":"https:\/\/doi.org\/10.1111\/jce.13818","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,6]]},"assertion":[{"value":"2018-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}