{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:30:36Z","timestamp":1774647036214,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:00:00Z","timestamp":1549065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Disturbance of sympathetic and vagal nervous system participates in the pathogenesis of hypertension and atrial fibrillation (AF). Renal denervation (RDN) can modulate autonomic nervous activity and reduce blood pressure (BP) in hypertensive patients. We aimed to evaluate the effect of RDN combined with pulmonary vein isolation (PVI) in patients with AF and hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical trials including randomized data comparing PVI plus RDN vs PVI alone were enrolled. Primary outcome was incidence of AF recurrence after procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 387 patients, of them 252 were randomized and were enrolled. Mean age was 57\u2009\u00b1\u200910 years, 71% were male, and mean left ventricular ejection fraction was 57.4%\u2009\u00b1\u20096.9%. Follow\u2010up for randomized data was 12 months. Overall comparison for primary outcome showed that PVI\u2009+\u2009RDN was associated with significantly lower AF recurrence as compared with PVI alone (35.8% vs 55.4%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). This advantageous effect was consistently maintained among randomized patients (37.3% vs 61.9%, odds ratio\u2009=\u20090.37, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.0001), and among patients with implanted devices for detection of AF recurrence (38.9% vs 61.6%, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.007). Post\u2010hoc sensitivity and regression analysis demonstrated very good stability of this primary result. Pooled Kaplan\u2010Meier analysis further showed that PVI\u2009+\u2009RDN was associated with significantly higher freedom from AF recurrence as compared with PVI alone (log\u2010rank test, \n<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Besides, RDN resulted in significant BP reduction without additionally increasing the risk of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>RDN may provide synergetic effects with PVI to reduce the burden of AF and improve BP control in patients with AF and uncontrolled hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13858","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T05:30:41Z","timestamp":1548394241000},"page":"658-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synergy of pulmonary vein isolation and catheter renal denervation in atrial fibrillation complicated with uncontrolled hypertension: Mapping the renal sympathetic nerve and pulmonary vein (the pulmonary vein isolation plus renal denervation strategy)?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-9573","authenticated-orcid":false,"given":"Shaojie","family":"Chen","sequence":"first","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien (CCB) Frankfurt am Main Frankfurt Academy For Arrhythmias (FAFA), Medizinische Klinik III, Agaplesion Markus Krankenhaus Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio G.","family":"Kiuchi","sequence":"additional","affiliation":[{"name":"School of Medicine\u2010Royal Perth Hospital Unit, University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehui","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chongqing Cardiac Arrhythmia Service Center The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaowen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai First People\u2019s Hospital\/Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Schratter","sequence":"additional","affiliation":[{"name":"Medizinische Abteilung mit Kardiologie Krankenhaus Hietzing Wien Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem\u2010Jan","family":"Acou","sequence":"additional","affiliation":[{"name":"Department of Cardiology AZ Delta Roeselare Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Meyer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kardiologie mit Schwerpunkt Elektrophysiologie Universit\u00e4res Herzzentrum Hamburg, Universit\u00e4tsklinikum Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"P\u00fcrerfellner","sequence":"additional","affiliation":[{"name":"Abteilung der kardialen Elektrophysiologie\/Kardiologie Akademisches Lehrkrankenhaus der Elisabethinen, Ordensklinikum Linz Elisabethinen Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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