{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:31:22Z","timestamp":1787729482499,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Currently, there is limited data regarding the impact of adjunctive renal sympathetic denervation (RSDN) with pulmonary vein isolation (PVI) in hypertensive patients with atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search for studies comparing RSDN\u2009+\u2009PVI vs PVI alone for AF and history of hypertension until 1 January 2019 was performed. The results were expressed as risk ratio (RR) for the categorical variables and mean difference (MD) for the continuous variables with 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of six eligible (four randomized and two prospective nonrandomized) studies consisting of 432 patients (306 paroxysmal AF and 126 persistent AF) were included (RSDN\u2009+\u2009PVI group: 186 patients and PVI group: 246 patients). Follow\u2010up is more than or equal to 1 year. Compared with PVI, RSDN\u2009+\u2009PVI significantly decreased the risk of AF recurrence (RR\u2009=\u20090.58, 95% confidence interval [CI]\u2009=\u20090.47\u20100.72, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001) on follow\u2010up. Fluoroscopy (MD\u2009=\u2009+5.53\u2009minutes, 95% CI\u2009=\u20090.76\u201010.31, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and procedure time (MD\u2009=\u2009+34.85\u2009minutes, 95% CI\u2009=\u200923.55\u201046.16, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.00001) was significantly longer with the PVI\u2009+\u2009RSDN group compared with PVI alone. There were no significant differences in complications between both groups. Test of heterogeneity was low for all clinical outcomes (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our meta\u2010analysis demonstrates that RSDN as an adjunct to PVI appears to be safe and improves clinical outcomes in both paroxysmal and persistent AF and history of hypertension<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13868","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T06:19:23Z","timestamp":1549433963000},"page":"702-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Renal sympathetic denervation improves clinical outcomes in patients undergoing catheter ablation for atrial fibrillation and history of hypertension: A meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-1545","authenticated-orcid":false,"given":"Varunsiri","family":"Atti","sequence":"first","affiliation":[{"name":"Department of Medicine Michigan State University\u2010Sparrow Hospital Lansing MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit K.","family":"Turagam","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular diseases Helmsley Electrophysiology Center, The Icahn School of Medicine at Mount Sinai New York City NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalaj","family":"Garg","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular diseases Helmsley Electrophysiology Center, The Icahn School of Medicine at Mount Sinai New York City NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanunjaya","family":"Lakkireddy","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular diseases Kansas City Heart Rhythm Institute Kansas City 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