{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:04:27Z","timestamp":1762999467487,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The recently developed second\u2010generation subcutaneous implantable cardioverter defibrillator (S\u2010ICD) and the intermuscular two\u2010incision implantation technique demonstrate potential favorable features that reduce inappropriate shocks and complications. However, data concerning large patient populations are lacking. The aim of this multicentre prospective study was to evaluate the safety and outcome of second\u2010generation S\u2010ICD using the intermuscular two\u2010incision technique in a large population study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>The study population included 101 consecutive patients (75% male; mean age, 45\u2009\u00b1\u200913 years) who received second\u2010generation S\u2010ICD (EMBLEM; Boston Scientific, Marlborough, MA) implantation using the intermuscular two\u2010incision technique as an alternative to the standard implantation technique. Twenty nine (29%) patients were implanted for secondary prevention. Twenty four (24%) patients had a previously implanted transvenous ICD. All patients were implanted without any procedure\u2010related complications. Defibrillation testing was performed in 80 (79%) patients, and ventricular tachycardia was successfully converted at less than or equal to 65\u2009J in 98.75% (79\/80) of patients without pulse generator adjustments. During a median follow\u2010up of 21\u2009\u00b1\u200910 months, no complications requiring surgical revision or local or systemic device\u2010related infections were observed. Ten patients (9.9%) received appropriate and successful shocks for ventricular arrhythmias. Three (2.9%) patients experienced inappropriate shocks due to oversensing the cardiac signal (<jats:italic>n<\/jats:italic>\u2009=\u20091), noncardiac signal (<jats:italic>n<\/jats:italic>\u2009=\u20091), and a combination of both cardiac and noncardiac signals (<jats:italic>n<\/jats:italic>\u2009=\u20091), with one patient requiring device explantation. No patients required device explantation due to antitachycardia pacing indications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to our multicentre study, second\u2010generation S\u2010ICD implanted with the intermuscular two\u2010incision technique is an available safe combination and appears to be associated with a low risk of complications, such as inappropriate shocks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13894","type":"journal-article","created":{"date-parts":[[2019,3,3]],"date-time":"2019-03-03T07:54:36Z","timestamp":1551599676000},"page":"854-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Multicentre experience with the second\u2010generation subcutaneous implantable cardioverter defibrillator and the intermuscular two\u2010incision implantation technique"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-9421","authenticated-orcid":false,"given":"Federico","family":"Migliore","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic And Vascular Sciences University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Mattesi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic And Vascular Sciences University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"De Franceschi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic And Vascular Sciences University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Allocca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital of Conegliano Treviso 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Division, Azienda Sanitaria Universitaria Integrata di Udine and IRCAB Foundation P.le Santa Maria della Misericordia Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Daleffe","sequence":"additional","affiliation":[{"name":"Cardiology Division, Azienda Sanitaria Universitaria Integrata di Udine and IRCAB Foundation P.le Santa Maria della Misericordia Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Fabris","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic And Vascular Sciences University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Marras","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dell\u00b4Angelo Hospital Mestre Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"De Lazzari","sequence":"additional","affiliation":[{"name":"Department 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