{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:55:22Z","timestamp":1790373322846,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","award":["External Research Protocol AF\u20103240"],"award-info":[{"award-number":["External Research Protocol AF\u20103240"]}],"id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Isolation of the pulmonary veins (PVI) has become a mainstay in atrial fibrillation (AFib) therapy. Lesions in left atrial tissue lead to scar formation and this may affect left atrial function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with paroxysmal AFib were randomly assigned in a 1:2 allocation scheme to radiofrequency (RF) ablation or cryoballoon. Real\u2010time three\u2010dimensional echocardiography was performed (under sinus rhythm in all cases) before ablation and at 1 and 3 months to evaluate the left atrial functional indices. The primary outcome measure was change in left atrial ejection fraction (LAEF) at 1 month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>120 patients were randomized (80 to cryoballoon, 40 to RF). The absolute change in LAEF at 1 month was 4.0 (Q1\u2010Q3, \u22120.1to 7.6)% in the cryoballoon group and \u22120.8 (Q1\u2010Q3, \u22121.9 to 0.9)% in the RF group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 for the comparison between groups). At 3 months, the corresponding changes were 6.7 (Q1\u2010Q3, 3.4\u201011.2)% and 0.7 (Q1\u2010Q3, \u22120.7 to 3.5)%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Overall, the rate of patients with lower LAEF at 3 months compared to baseline was 2.5% in the cryoballoon group and 32.5% in the RF group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). AFib recurrence rate at 6 months was higher in patients with decreased LAEF (odds ratio, 6.2; 95% confidence interval, 2.0\u201019.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Cryo\u2010LAEF study prospectively compared the effects of RF and cryoballoon ablation on left atrial function. Both at 1 and 3 months postablation, LAEF was either improved or stable in both ablation groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13933","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T12:54:19Z","timestamp":1554209659000},"page":"991-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effect of cryoballoon and radiofrequency ablation for pulmonary vein isolation on left atrial function in patients with nonvalvular paroxysmal atrial fibrillation: A prospective randomized study (Cryo\u2010LAEF study)"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-3850","authenticated-orcid":false,"given":"Georgios","family":"Giannopoulos","sequence":"first","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. 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Gennimatas\u201d Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Letsas","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Evangelismos General Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Tsiachris","sequence":"additional","affiliation":[{"name":"Athens Heart Center Athens Medical Center Marousi Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Tsoukala","sequence":"additional","affiliation":[{"name":"Department of Cardiology Athens General Hospital \u201cG. 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