{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:52:43Z","timestamp":1792180363946,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001857"],"award-info":[{"award-number":["UL1\u2010TR\u2010001857"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Adenosine challenge (AC) can be used to evaluate possible Wolff\u2010Parkinson\u2010White (WPW) pattern on an electrocardiogram (ECG). Despite the use of this technique, there is a paucity of studies in the pediatric population evaluating the efficacy, safety, and outcomes of this testing modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>All ACs performed from January 2009 to June 2017 were retrospectively reviewed. Patient demographics, adenosine dosing, results, adverse effects, and outcomes including results of electrophysiology studies (EPS) were reviewed. Analysis was conducted between AC positive and negative cohorts. ECG criteria of shortest PR interval, longest QRS duration, and the number of suspected pre\u2010excited leads were evaluated for inter\u2010rater reliability and correlation to positive AC. Fifty\u2010six AC (n = 51) were performed (median age, 13.8; range, 0.3\u201020 years). Forty\u2010one AC were pre\u2010EPS and 15 post\u2010EPS due to concern for recurrent WPW. Thirty\u2010one (76%) pre\u2010EPS AC were negative, 9 (22%) positive, and 1 (2%) equivocal. EPS was performed following seven positive AC revealing 5 (71%) left posterior and 2 (29%) right posteroseptal AP. The 15 post\u2010EPS AC were all found to be negative. Mean effective adenosine dose was 0.2 \u00b1 0.11 mg\/kg. No adverse events were reported. Mean follow up duration after AC was 314 \u00b1 482 days with no documented arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adenosine challenge is an effective and safe testing modality for subtle WPW in the pediatric population. In our population, there were no adverse events or documented arrhythmias in patients following a negative study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13935","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T12:57:36Z","timestamp":1554209856000},"page":"1036-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Utility and safety of adenosine challenge for subtle ventricular pre\u2010excitation in the pediatric population"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1029-800X","authenticated-orcid":false,"given":"Christopher W.","family":"Follansbee","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee B.","family":"Beerman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5799-9033","authenticated-orcid":false,"given":"Marnie","family":"Bertolet","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and The Clinical and Translational Science Institute, Graduate School of Public Health University of Pittsburgh Pittsburgh 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