{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:44:16Z","timestamp":1772329456804,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Implantation of the MICRA Leadless pacemaker requires the use of a 27 French introducer, blunt delivery system and device fixation to the myocardium via nitinol tines. While prior studies have proven its safety, it is unclear whether performing this procedure with uninterrupted anticoagulation exposes patients to increased risks. We sought to investigate the feasibility and safety of continuing therapeutic anticoagulation during the periprocedural period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated all patients undergoing MICRA placement at our institution between April 2014 and August 2018 with complete follow\u2010up data (n\u2009=\u2009170). Patients were stratified into two groups: those on active anticoagulation (OAC, n\u2009=\u200926), defined as having an International normalized ratio &gt;2.0 or having continued a direct oral anticoagulant, and those not anticoagulated (Off\u2010OAC, n\u2009=\u2009144). We evaluated for a composite outcome of all major complications, including access site complications and pericardial effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OAC and Off\u2010OAC groups had similar mean age (74\u2009\u00b1\u200913 vs 75\u2009\u00b1\u200913 years; <jats:italic>P<\/jats:italic>\u2009=\u2009.914). The OAC group had a nonsignificantly lower prevalence of end\u2010stage renal disease (8% vs 17%; <jats:italic>P<\/jats:italic>\u2009=\u2009.375) and aspirin use (27% vs 47%; <jats:italic>P<\/jats:italic>\u2009=\u2009.131). Those in the OAC group were more likely to be on warfarin than those in the Off\u2010OAC group (81% vs 30%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The rate of the composite endpoint was similar between the OAC and Off\u2010OAC groups (3.8 % vs 1.4%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u2009.761). Length of stay was similar between groups (1.3\u2009\u00b1\u20092.6 vs 2.3\u2009\u00b1\u20093.4 days; <jats:italic>P<\/jats:italic>\u2009=\u20090.108).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Continuation of therapeutic anticoagulation during MICRA implantation appears to be feasible, safe and associated with shorter hospitalization among appropriately selected individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13965","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T12:19:13Z","timestamp":1556799553000},"page":"1313-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of Micra leadless pacemaker implantation with uninterrupted anticoagulation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6389-0643","authenticated-orcid":false,"given":"Soroosh","family":"Kiani","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George B.","family":"Black","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birju","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Massad","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshar V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal M.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Hoskins","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"De Lurgio","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshul M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand D.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel R.","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy B.","family":"Westerman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-9330","authenticated-orcid":false,"given":"Michael S.","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-7177","authenticated-orcid":false,"given":"Mikhael F.","family":"El\u2010Chami","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine Emory University School of Medicine  Atlanta Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.017"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2011.03150.x"},{"issue":"4","key":"e_1_2_6_1_4_1","first-page":"249","article-title":"Leadless pacemakers: a contemporary review","volume":"15","author":"Bhatia N","year":"2018","journal-title":"J Geriatr Cardiol"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv096"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.08.005"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511643"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.017"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302946"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy413"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507192"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13092"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv375"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur038"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.12.011"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.039"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn099"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft209"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2018.01.006"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjce.13965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.13965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.13965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T05:06:20Z","timestamp":1694322380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.13965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/jce.13965"],"URL":"https:\/\/doi.org\/10.1111\/jce.13965","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,16]]},"assertion":[{"value":"2019-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}