{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:04:09Z","timestamp":1769123049008,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270339"],"award-info":[{"award-number":["81270339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sympathetic neural activation plays a key role in the incidence and maintenance of acute myocardial infarction (AMI) induced ventricular arrhythmia (VA). Furthermore, previous studies showed that AMI might induce microglia and sympathetic activation and that microglial activation might contribute to sympathetic activation. Recently, studies showed that light emitting diode (LED) therapy might attenuate microglial activation. Therefore, we hypothesized that LED therapy might reduce AMI\u2010induced VA by attenuating microglia and sympathetic activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty anesthetized rats were randomly divided into three groups: the Control group (<jats:italic>n<\/jats:italic>\u2009=\u20096), AMI group (<jats:italic>n<\/jats:italic>\u2009=\u200912), and AMI\u2009+\u2009LED group (<jats:italic>n<\/jats:italic>\u2009=\u200912). Electrocardiogram (ECG) and left stellate ganglion (LSG) neural activity were continuously recorded. The incidence of VAs was recorded during the first hour after AMI. Furthermore, we sampled the brain and myocardium tissue of the different groups to examine the microglial activation and expression of nerve growth factor (NGF), interleukin\u201018 (IL\u201018), and IL\u20101\u03b2, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the AMI group, LED therapy significantly reduced the incidence of AMI\u2010induced VAs (ventricular premature beats [VPB] number: 85.08\u2009\u00b1\u200913.91 vs 27.5\u2009\u00b1\u20099.168, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; nonsustained ventricular tachycardia (nSVT) duration: 34.39\u2009\u00b1\u20098.562 vs 9.005\u2009\u00b1\u20093.442, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05; nSVT number: 18.92\u2009\u00b1\u20094.52 vs 7.583\u2009\u00b1\u20093.019, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05; incidence rate of SVT\/VF: 58.33% vs. 8.33%, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and reduced the LSG neural activity (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) in the AMI\u2009+\u2009LED group. Furthermore, LED significantly attenuated microglial activation and reduced IL\u201018, IL\u20101\u03b2, and NGF expression in the peri\u2010infarct myocardium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LED therapy may protect against AMI\u2010induced VAs by suppressing sympathetic neural activity and the inflammatory response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13974","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T10:30:46Z","timestamp":1558261846000},"page":"1138-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Noninvasive light emitting diode therapy: A novel approach for postinfarction ventricular arrhythmias and neuroimmune modulation"],"prefix":"10.1111","volume":"30","author":[{"given":"Songyun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Renmin Hospital of Wuhan University 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