{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:54:44Z","timestamp":1789397684038,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ventricular tachycardia (VT) is frequently encountered in patients with repaired and unrepaired congenital heart disease (CHD), causing significant morbidity and sudden cardiac death. Data regarding underlying VT mechanisms and optimal ablation strategies in these patients remain limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the electrophysiologic mechanisms, ablation strategies, and long\u2010term outcomes in patients with CHD undergoing VT ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight patients (mean age 41.3\u2009\u00b1\u200913.3 years, 77.1% male) with CHD underwent a total of 57 VT ablation procedures at two centers from 2000 to 2017. Electrophysiologic and follow\u2010up data were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 77 different VTs induced at initial or repeat ablation, the underlying mechanism in 62 (81.0%) was due to scar\u2010related re\u2010entry; the remaining included four His\u2010Purkinje system\u2013related macrore\u2010entry VTs and focal VTs mainly originating from the outflow tract region (8 of 11, 72.7%). VT\u2010free survival after a single procedure was 72.9% (35 of 48) at a median follow\u2010up of 53 months. VT\u2010free survival after multiple procedures was 85.4% (41 of 48) at a median follow\u2010up of 52 months. There were no major complications. Three patients died during the follow\u2010up period from nonarrhythmic causes, including heart failure and cardiac surgery complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While scar\u2010related re\u2010entry is the most common VT mechanism in patients with CHD, importantly, nonscar\u2010related VT may also be present. In experienced tertiary care centers, ablation of both scar\u2010related and nonscar\u2010related VT in patients with CHD is safe, feasible, and effective over long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.13996","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T06:53:24Z","timestamp":1558421604000},"page":"1560-1568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Long term follow\u2010up after ventricular tachycardia ablation in patients with congenital heart disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Jiandu","family":"Yang","sequence":"first","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"},{"name":"State Key Laboratory of Cardiovascular Disease, Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brunnquell","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology University of Colorado Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-8899","authenticated-orcid":false,"given":"Jackson J.","family":"Liang","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Callans","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin C.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lin","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-4857","authenticated-orcid":false,"given":"David S.","family":"Frankel","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kay","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado University of Colorado Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":false,"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8514-1165","authenticated-orcid":false,"given":"Wendy","family":"Tzou","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology University of Colorado Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7070-0307","authenticated-orcid":false,"given":"William H.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology University of Colorado Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolun","family":"Liu","sequence":"additional","affiliation":[{"name":"Electrophysiology Section, Division of Cardiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Ruckdeschel","sequence":"additional","affiliation":[{"name":"Philadelphia Adult Congenital Heart Center &amp; 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