{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:10:27Z","timestamp":1774437027461,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by an epicardial (EPI) to endocardial (ENDO) fibrofatty infiltration of the RV predisposing to both EPI and ENDO ventricular tachycardia (VT). The relative timing between the VT QRS onset on the far\u2010field ventricular electrogram (VEGM) to the local activation time recorded at the RV apex on the near\u2010field VEGM from stored implantable cardioverter\u2010defibrillator (ICD) events of VT can be helpful to discriminate ENDO from EPI VT in ARVC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analyzed consecutive ARVC patients undergoing catheter ablation between 2006 and 2018. Only patients with retrievable ICD VEGMs of clinical VTs which could be matched with VTs induced at the time of ablation were included. A total of 26 VT events (16 ENDO, 10 EPI) from 19 ARVC patients were examined, yielding a mean far\u2010field to near\u2010field interval of 33\u2009\u00b1\u200915\u2009ms for ENDO VTs and 52\u2009\u00b1\u200920\u2009ms for EPI VTs (<jats:italic>P<\/jats:italic>\u2009=\u2009.020). At receiver\u2010operating characteristic analysis, a far\u2010field to a near\u2010field interval of 60\u2009ms or more ruled out ENDO VTs in 16 (100%) cases and identified EPI VTs with a positive predictive value (PPV) of 100% and a negative predictive value (NPV) of 73%. An interval of less than or equal to 30\u2009ms ruled out EPI VTs in eight (80%) cases and diagnosed ENDO VTs with a PPV of 80% and an NPV of 50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Far\u2010field to near\u2010field ICD VEGM timing may be used to predict ENDO vs EPI VT in ARVC before ablation, indicating an ENDO origin if the timing is less than or equal to 30\u2009ms and an EPI origin if greater than or equal to 60\u2009ms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14014","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T06:15:07Z","timestamp":1560320107000},"page":"1526-1534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Usefulness of ICD electrograms analysis to distinguish endocardial vs epicardial ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy"],"prefix":"10.1111","volume":"30","author":[{"given":"Santhisri","family":"Kodali","sequence":"first","affiliation":[{"name":"Department of Cardiac Electrophysiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Callans","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7331-448X","authenticated-orcid":false,"given":"Erica S.","family":"Zado","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-9423","authenticated-orcid":false,"given":"Francis E.","family":"Marchlinski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-9666","authenticated-orcid":false,"given":"Pasquale","family":"Santangeli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Electrophysiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.2.384"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000145154.02436.90"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.983"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.06.024"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02233.x"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12019"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12444"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.840827"},{"key":"e_1_2_7_1_10_1","first-page":"S173","article-title":"Electrogram characteristics of the epicardial ventricular tachycardia substrate in nonischemic cardiomyopathy","volume":"5","author":"Cano O","year":"2008","journal-title":"Heart Rhythm"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.11.1288"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.09.088"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1996.tb00559.x"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003562"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.01.009"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.963066"},{"issue":"4","key":"e_1_2_7_1_17_1","first-page":"607","article-title":"Safety, long\u2010term outcomes and predictors of recurrence after first\u2010line combined endoepicardial ventricular tachycardia substrate ablation in arrhythmogenic cardiomyopathy. Impact of arrhythmic substrate distribution pattern. A prospective multicentre study","volume":"19","author":"Berruezo A","year":"2017","journal-title":"Europace"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.087"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02286.x"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000935"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02127.x"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.04.031"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.967935"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.14014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T20:47:29Z","timestamp":1694292449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.14014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/jce.14014"],"URL":"https:\/\/doi.org\/10.1111\/jce.14014","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]},"assertion":[{"value":"2019-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}