{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:28:20Z","timestamp":1790738900495,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/15\/53\/31615"],"award-info":[{"award-number":["FS\/15\/53\/31615"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>His\u2010bundle pacing (HBP) provides physiological ventricular activation. Observational studies have demonstrated the techniques\u2019 feasibility; however, data have come from a limited number of centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We set out to explore the contemporary global practice in HBP focusing on the learning curve, procedural characteristics, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective, multicenter observational study of patients undergoing attempted HBP at seven centers. Pacing indication, fluoroscopy time, HBP thresholds, and lead reintervention and deactivation rates were recorded. Where centers had systematically recorded implant success rates from the outset, these were collated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 529 patients underwent attempted HBP during the study period (2014\u201019) with a mean follow\u2010up of 217\u2009\u00b1\u2009303 days. Most implants were for bradycardia indications.<\/jats:p>\n                    <jats:p>In the three centers with the systematic collation of all attempts, the overall implant success rate was 81%, which improved to 87% after completion of 40 cases.<\/jats:p>\n                    <jats:p>All seven centers reported data on successful implants. The mean fluoroscopy time was 11.7\u2009\u00b1\u200912.0\u2009minutes, the His\u2010bundle capture threshold at implant was 1.4\u2009\u00b1\u20090.9\u2009V at 0.8\u2009\u00b1\u20090.3\u2009ms, and it was 1.3\u2009\u00b1\u20091.2\u2009V at 0.9\u2009\u00b1\u20090.2\u2009ms at last device check.<\/jats:p>\n                    <jats:p>HBP lead reintervention or deactivation (for lead displacement or rise in threshold) occurred in 7.5% of successful implants.<\/jats:p>\n                    <jats:p>There was evidence of a learning curve: fluoroscopy time and HBP capture threshold reduced with greater experience, plateauing after approximately 30\u201050 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that it is feasible to establish a successful HBP program, using the currently available implantation tools. For physicians who are experienced at pacemaker implantation, the steepest part of the learning curve appears to be over the first 30\u201050 cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.14064","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T08:39:11Z","timestamp":1563266351000},"page":"1984-1993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["His bundle pacing, learning curve, procedure characteristics, safety, and feasibility: Insights from a large international observational study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-7358","authenticated-orcid":false,"given":"Daniel","family":"Keene","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahran D","family":"Arnold","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-6601","authenticated-orcid":false,"given":"Marek","family":"Jastrz\u0119bski","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Interventional Electrocardiology and Hypertension Jagiellonian University Collegium Medicum  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4393-5338","authenticated-orcid":false,"given":"Haran","family":"Burri","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital, Cardiology  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-6559","authenticated-orcid":false,"given":"Steven","family":"Zweibel","sequence":"additional","affiliation":[{"name":"Department of Interventional Electrophysiology, Hartford Hospital Interventional Electrophysiology  Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Crespo","sequence":"additional","affiliation":[{"name":"Department of Interventional Electrophysiology, Hartford Hospital Interventional Electrophysiology  Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badrinathan","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Cardiology Department Great Western Hospitals NHS Foundation Trust  Swindon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukhbinder","family":"Bassi","sequence":"additional","affiliation":[{"name":"Cardiology Department Sherwood Forest Hospitals NHS Foundation Trust  Sutton, Ashfield"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Joghetaei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Klinikum Landkreis Erding, Cardiology  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Swift","sequence":"additional","affiliation":[{"name":"Cardiology Department Great Western Hospitals NHS Foundation Trust  Swindon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5644-5963","authenticated-orcid":false,"given":"Pawel","family":"Moskal","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Interventional Electrocardiology and Hypertension Jagiellonian University Collegium Medicum  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrel P","family":"Francis","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Foley","sequence":"additional","affiliation":[{"name":"Cardiology Department Great Western Hospitals NHS Foundation Trust  Swindon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Shun\u2010Shin","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary I","family":"Whinnett","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  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