{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:43Z","timestamp":1740137143298,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prognostic significance of P\u2010wave morphology in patients with coronary artery disease (CAD) is not well\u2010known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1946 patients with angiographically verified CAD were included in the Innovation to reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS) study. The P\u2010wave morphology could be analyzed in 1797 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 7.4\u2009\u00b1\u20092.0 years, a total of 168 (9.3%) patients died or experienced resuscitation from sudden cardiac arrest (SCA), 43 (2.4%) patients experienced sudden cardiac death (SCD) or were resuscitated from SCA, 37 (2.1%) patients succumbed to non\u2010SCD (NSCD), and 88 (4.9%) patients to noncardiac death (NCD). Of the P\u2010wave parameters, the absolute P\u2010wave residuum (PWR), the heterogeneity of the P\u2010wave morphology (PWH), and the P\u2010wave duration (Pdur) had the closest univariate association with the risk of SCD\/SCA (0.0038\u2009\u00b1\u20090.0026 vs 0.0022\u2009\u00b1\u20090.0017, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; 11.0\u2009\u00b1\u20095.2 vs 8.6\u2009\u00b1\u20093.6, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; 142.7\u2009\u00b1\u200916.9 vs 134.8\u2009\u00b1\u200914.3\u2009milliseconds, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01; SCD\/SCA vs no SCD\/SCA, respectively). After adjustments with factors that were associated with the risk of SCD\/SCA, such as diabetes, smoking, left bundle branch block, high\u2010sensitivity C\u2010reactive protein, and high\u2010sensitivity troponin T, PWR (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), PWH (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), and Pdur (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) still predicted SCD\/SCA but not non\u2010sudden cardiac death. When these parameters were added to the SCD\/SCA clinical risk model, the discrimination and reclassification accuracy of the risk model increased significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and the C\u2010index increased from 0.745 to 0.787.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The P\u2010wave morphology parameters independently\u00a0predict SCD\/SCA in patients with CAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14066","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T12:37:47Z","timestamp":1563280667000},"page":"2051-2060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic significance of P\u2010wave morphology in patients with coronary artery disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Santeri","family":"Nortamo","sequence":"first","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idamaria","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Passi","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Tulppo","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olavi H.","family":"Ukkola","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Juhani","family":"Junttila","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti M.","family":"Kiviniemi","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"Kentt\u00e4","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki V.","family":"Huikuri","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-3985","authenticated-orcid":false,"given":"Juha S.","family":"Perki\u00f6m\u00e4ki","sequence":"additional","affiliation":[{"name":"Research Unit of Internal Medicine, Medical Research Center Oulu University of Oulu and Oulu University Hospital Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"e_1_2_7_1_2_1","unstructured":"World Health Organization2017. 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