{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:39:49Z","timestamp":1790419189313,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1R56HL133182\u201001 (PI: Huizar)"],"award-info":[{"award-number":["1R56HL133182\u201001 (PI: Huizar)"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL139874\u201001 (PI: Huizar)"],"award-info":[{"award-number":["1R01HL139874\u201001 (PI: Huizar)"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Frequent premature ventricular contractions (PVCs) can cause cardiomyopathy (CM). Postextrasystolic potentiation (PESP) and irregularity have been in implicated as triggers of PVC\u2010CM. Because both phenomena can also be found in premature atrial contractions (PACs), it is speculated that frequent PACs have similar consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A single\u2010center, retrospective study included all consecutive patients undergoing a 14\u2010day Holter monitors (November 2014 to\u00a0October 2016). Patients were divided into four groups by ectopy burden group 1 (&lt;1%) and remaining by tertiles (group 2\u20104). Echocardiographic and arrhythmic data were compared between PAC and PVC burdens. In addition, a translational PAC animal model was used to assess the chronic effects of frequent PACs. A total 846 patients were reviewed. In contrast to PVCs, we found no difference in left ventricular ejection fraction (LVEF), end\u2010systolic and end\u2010diastolic dimensions and presence of CM (LVEF &lt;50%) between different PAC groups. Multivariate regression analysis demonstrated that only PVC burden predicted low EF (odds ratio, 1.1; confidence interval, 1.03\u20101.13; <jats:italic>P<\/jats:italic>\u2009=\u2009.001). While there was a weak correlation between PAC burden and supraventricular tachycardia (SVT) episodes and atrial fibrillation (AF) burden (<jats:italic>r<\/jats:italic>\u2009=\u20090.19; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), there was no correlation between PAC burden and LVEF or CM. Finally, atrial bigeminy in our animal model did not significantly decrease LVEF after 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PAC burden is associated with increased AF and SVT episodes. In contrast to a high PVC burden, a high PAC burden is not associated with CM. Our findings suggest that heart rate irregularity and\/or PESP may play a minimal role in the pathophysiology of PVC\u2010CM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14067","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T12:29:47Z","timestamp":1563280187000},"page":"1952-1959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Consequences of chronic frequent premature atrial contractions: Association with cardiac arrhythmias and cardiac structural changes"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9010-0256","authenticated-orcid":false,"given":"Sampath","family":"Gunda","sequence":"first","affiliation":[{"name":"Pauley Heart Center Virginia Commonwealth University  Richmond 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