{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:47Z","timestamp":1787015387665,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Subclinical atrial fibrillation (AF), in the form of cardiac implantable device\u2010detected atrial high rate episodes (AHREs), has been associated with increased thromboembolism. An implantable cardioverter\u2010defibrillator (ICD) lead with a floating atrial dipole may permit a single lead (DX) ICD system to detect AHREs. We sought to assess the utility of the DX ICD system for subclinical AF detection in patients, with a prospective multicenter, cohort\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      One hundred fifty patients without prior history of AF (age 59\u2009\u00b1\u200913 years; 108 [72%] male) were enrolled into the DX cohort and implanted with a Biotronik DX ICD system at eight centers. Age\u2010, sex\u2010, and left ventricular ejection fraction\u2010matched single\u2010 and dual\u2010chamber ICD cohorts were derived from a Cornell database and from the IMPACT trial, respectively. The primary endpoint were AHRE detection at 12 months. During median 12 months follow\u2010up, AHREs were detected in 19 (13%) patients in the DX, 8 (5.3%) in the single\u2010chamber, and 19 (13%) in the dual\u2010chamber cohorts. The rate of AHRE detection was significantly higher in the DX cohort compared to the single\u2010chamber cohort (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.026), but not significantly different compared to the dual\u2010chamber cohort. There were no inappropriate ICD therapies in the DX cohort. At 12 months, only 3.0% of patients in the DX cohort had sensed atrial amplitudes less than 1.0\u2009mV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Use of a DX ICD lead allows subclinical AF detection with a single lead DX system that is superior to that of a conventional single\u2010chamber ICD system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jce.14081","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T01:24:20Z","timestamp":1563758660000},"page":"1994-2001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Subclinical atrial fibrillation detection with a floating atrial sensing dipole in single lead implantable cardioverter\u2010defibrillator systems: Results of the SENSE trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7158-8305","authenticated-orcid":false,"given":"George","family":"Thomas","sequence":"first","affiliation":[{"name":"Division of Cardiology, Weill Cornell Medicine NewYork\u2010Presbyterian Hospital New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Weill Cornell Medicine NewYork\u2010Presbyterian Hospital New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Doppalapudi","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Richards","sequence":"additional","affiliation":[{"name":"Northwest Ohio Cardiology Consultants Toledo Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei","family":"Iwai","sequence":"additional","affiliation":[{"name":"Division of Cardiology Westchester Medical Center Valhalla New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3580-2092","authenticated-orcid":false,"given":"Emile G.","family":"Daoud","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine The Ohio State University Medical Center Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Houmsse","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine The Ohio State University Medical Center Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvindh N.","family":"Kanagasundram","sequence":"additional","affiliation":[{"name":"Division of Cardiology Vanderbilt University Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet K.","family":"Mainigi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology Albert Einstein Medical Center  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Lubitz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-9360","authenticated-orcid":false,"given":"Jim W.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Weill Cornell Medicine NewYork\u2010Presbyterian Hospital New York New 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