{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:29:51Z","timestamp":1767990591773,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with cardiac sarcoidosis (CS) may present with arrhythmic events (AE): atrioventricular block (AVB) and\/ or ventricular arrhythmias (VA). We sought to: (a) use regional analysis of cardiac magnetic resonance imaging (CMR) to describe anatomic and functional phenotypes of patients with CS and AE; (b) Assess the association of regional CMR abnormalities with the combined endpoint of death, heart transplantation (HT) and AE; and (c) use machine learning (ML) to predict the combined endpoint based on CMR features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>we included 76 patients with CS and CMR. We analyzed cine images to determine regional longitudinal (LS) and radial strain (RS); and late gadolinium enhancement imaging to determine regional scar burden (%scar).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AVB (n\u2009=\u20097), compared with those without, had higher %scar in the anterior (21.8 \u00b1 27.4 vs 5.1 \u00b1 8.9; <jats:italic>P<\/jats:italic>\u2009=\u20090.0005) and anteroseptal (19.3\u2009\u00b1\u200924.5 vs 3.5\u2009\u00b1\u20095.5; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001) walls. Patients with VA (n\u2009=\u200912), compared with those without, had higher %scar in the basal inferoseptum (20.4\u2009\u00b1\u200930.8 vs 8.3\u2009\u00b1\u200913.4; <jats:italic>P<\/jats:italic>\u2009=\u2009.03). During mean follow\u2010up of 4.4\u2009\u00b1\u20093.3 years, four patients died or underwent HT; eight had VA; and zero developed AVB. Multiple regional abnormalities were associated with the combined endpoint, including scar in the anteroseptal wall (HR 1.06 [1.02\u20101.09] per 1%scar increase, <jats:italic>P<\/jats:italic>\u2009=\u2009.002). The ML algorithm predicted the combined endpoint with a C\u2010statistic of 0.91.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regional CMR abnormalities are associated with AE in patients with CS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14082","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T05:23:41Z","timestamp":1563773021000},"page":"1967-1976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Regional abnormalities on cardiac magnetic resonance imaging and arrhythmic events in patients with cardiac sarcoidosis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-3779","authenticated-orcid":false,"given":"David R.","family":"Okada","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Assis","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arsalan","family":"Derakhshan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zain","family":"Gowani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharath","family":"Ambale\u2010Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Radiology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha A.","family":"Gilotra","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan L.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Radiology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald D.","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-9433","authenticated-orcid":false,"given":"Hugh","family":"Calkins","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"},{"name":"Department of Radiology Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao A. C.","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harikrishna","family":"Tandri","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-3019","authenticated-orcid":false,"given":"Jonathan","family":"Chrispin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine Johns Hopkins Hospital Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.605"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.043"},{"issue":"15","key":"e_1_2_9_1_4_1","first-page":"e190","article-title":"AHA\/ACC\/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"2018","author":"Al\u2010Khatib SM","year":"2017","journal-title":"Heart Rhythm"},{"key":"e_1_2_9_1_5_1","first-page":"133","article-title":"Efficacy of corticosteroids in sarcoidosis presenting with atrioventricular block","volume":"20","author":"Kato Y","year":"2003","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12401"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.959254"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.07.007"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.11.028"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.006145"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.02.010"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007030"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.05.009"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.000289"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.022"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005973"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-35"}],"container-title":["Journal of Cardiovascular Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jce.14082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jce.14082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:01:04Z","timestamp":1694041264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jce.14082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1111\/jce.14082"],"URL":"https:\/\/doi.org\/10.1111\/jce.14082","archive":["Portico"],"relation":{},"ISSN":["1045-3873","1540-8167"],"issn-type":[{"value":"1045-3873","type":"print"},{"value":"1540-8167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"2019-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}