{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:22:05Z","timestamp":1776867725610,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Little is known about how genetic predisposition and fibrosis relate in atrial fibrillation (AF). Hence, we sought to determine whether the genetic variants and biomarkers for fibrosis enhance prediction of outcomes after catheter ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Consecutive patients who underwent catheter ablation of AF (paroxysmal, 158; nonparoxysmal, 137) or supraventricular tachycardia without AF (n\u2009=\u200970) were studied retrospectively. Plasma levels of transforming growth factor\u00a0\u03b21 (TGF\u2010\u03b21), tissue inhibitor of metalloproteinase 1 (TIMP\u20101), and 4q25 single\u2010nucleotide polymorphisms (SNPs) (rs10033464 and rs220073) were measured. Mean plasma levels of both TGF\u2010\u03b21 and TIMP\u20101 were higher in patients with AF than in the control (all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Plasma levels of TIMP\u20101 were higher in patients with recurrence compared with those without recurrence (<jats:italic>P<\/jats:italic>\u2009=\u2009.039). Patients with variant alleles of rs10033464 showed increased recurrence after catheter ablation in patients with paroxysmal AF including after adjustment (<jats:italic>P<\/jats:italic>\u2009=\u2009.027). Patients with TIMP\u20101\u2009&lt;\u2009107\u2009ng\/mL and no variant allele (GG) at rs10033464 had lower recurrence rates compared with other groups in those with paroxysmal AF (logrank; <jats:italic>P<\/jats:italic>\u2009=\u2009.007), whereas there was no significant difference among those patients with persistent forms of AF. Inclusion of biomarkers and genotype improved discrimination of AF recurrence in patients with paroxysmal AF (<jats:italic>C<\/jats:italic>\u2010statistic .499 vs .600).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of plasma TIMP\u20101 concentrations less than 107\u2009ng\/mL and the absence of a variant allele at rs10033464 was associated with lower recurrence rates in patients with paroxysmal AF. This study suggests that 4q25 SNPs and biomarkers for fibrosis may provide additive value in risk stratification for AF recurrence after catheter ablation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14104","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T11:10:20Z","timestamp":1565262620000},"page":"1904-1913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chromosome 4q25 variants and biomarkers of myocardial fibrosis in patients with atrial fibrillation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-508X","authenticated-orcid":false,"given":"Jong\u2010Il","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Korea University College of Medicine and Korea University Medical Center Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Soo","family":"Baek","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Inha University Hospital Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-9079","authenticated-orcid":false,"given":"Seung Young","family":"Roh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Korea University College of Medicine and Korea University Medical Center Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-2404","authenticated-orcid":false,"given":"Jonathan P.","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke Center for Atrial Fibrillation, Duke Clinical Research Institute Duke University Medical Center Durham North 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