{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T09:36:29Z","timestamp":1772876189382,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Electrocardiographic T<jats:sub>peak<\/jats:sub>\u2010T<jats:sub>end<\/jats:sub> interval (Tp\u2010Te) is a promising marker for the prediction of ventricular tachycardia and\/or ventricular fibrillation (VT\/VF). The study was aimed to compare single\u2010lead vs multilead Tp\u2010Te variables as VT\/VF predictors in experimental ischemia\/reperfusion model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Computer simulations were done using the ECGSIM model with an ischemic region set in anterior left ventricular apex. In 18 anesthetized cats, myocardial ischemia was induced by 30\u2010minute ligation of left anterior descending coronary artery followed by reperfusion. Body surface ECGs in limb leads and modified precordial leads were recorded. Tp\u2010Te was detected automatically in individual leads with a custom\u2010designed parametric algorithm. Tp\u2010Te dispersion and total Tp\u2010Te were calculated as a difference between the maximal and minimal value of individual Tp\u2010Te(s) and an interval between the earliest Tpeak and the latest Tend throughout all leads, respectively.<\/jats:p><jats:p>Simulations showed that the increase of local, but not total, dispersion of repolarization characteristic for ischemic damage led to nonuniform shortening of T\u2010peak times across 12 standard leads, which in turn resulted in the increase of single\u2010lead Tp\u2010Te(s), total Tp\u2010Te and Tp\u2010Te dispersion. Animals experienced VT\/VF showed increased Tp\u2010Te dispersion and total Tp\u2010Te during reperfusion. In univariate logistic regression analysis, only the Tp\u2010Te dispersion at the beginning of reperfusion was associated with the VT\/VF incidence. According to ROC curve analysis, the optimal cut\u2010off value of the Tp\u2010Te dispersion was 17 ms (sensitivity 0.71, specificity 0.80).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reperfusion VT\/VFs were independently predicted by increased Tp\u2010Te dispersion, which suggests the importance of multi\u2010lead evaluation of Tp\u2010Te intervals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14105","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T05:09:15Z","timestamp":1565586555000},"page":"2090-2097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multi\u2010lead vs single\u2010lead T<sub>peak<\/sub>\u2010T<sub>end<\/sub> interval measurements for prediction of reperfusion ventricular tachyarrhythmias"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-2675","authenticated-orcid":false,"given":"Ksenia","family":"Sedova","sequence":"first","affiliation":[{"name":"Department of Biomedical Technology, Faculty of Biomedical Engineering Czech Technical University in Prague  Kladno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktorija","family":"Galinyte","sequence":"additional","affiliation":[{"name":"Department of Biomedical Technology, Faculty of Biomedical Engineering Czech Technical University in Prague  Kladno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Arteyeva","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center, Ural Branch Russian Academy of Sciences  Syktyvkar 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