{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:32:15Z","timestamp":1774344735194,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In patients with early repolarization patterns on ECG, many researchers have studied to find predictors of fatal arrhythmia. However, there are no satisfying clinical predictors. We evaluated the value of the T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> interval on pseudo\u2010ECG in canine myocardial wedge preparation models of early repolarization syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Transmural pseudo\u2010ECG and endocardial\/epicardial action potentials were recorded from coronary\u2010perfused canine left ventricular wedge preparations (<jats:italic>n<\/jats:italic>\u2009=\u200934). The I<jats:sub>to<\/jats:sub> agonist NS5806 (8\u201010\u2009\u00b5M), the calcium channel blocker verapamil (3\u2009\u00b5M) and acetylcholine (2\u20103\u2009\u00b5M) were used to mimic the disease model. A ventricular arrhythmia induction test was performed. QT<jats:sub>peak<\/jats:sub>, QT<jats:sub>end<\/jats:sub>, T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub>, and T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub>\/QT<jats:sub>end<\/jats:sub> were measured at 15 to 20\u2009minutes after the provocative agent infusion. Polymorphic ventricular tachycardias (pVT) developed in 23 of the 34 preparations (67%). The maximal values of T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> and T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub>\/QT<jats:sub>end<\/jats:sub> were recorded just before pVT induction. At baseline, without the provocative agents, T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> and T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub>\/QT<jats:sub>end<\/jats:sub> were not different between pVT\u2010induced and pVT\u2010noninduced preparations. The T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> of the pVT\u2010induced preparations was longer than that of non\u2010induced preparations (58\u2009\u00b1\u200926.8 msec vs 33\u2009\u00b1\u20096.8\u2009msec, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub>\/QT<jats:sub>end<\/jats:sub> of pVT\u2010 induced preparations was larger than that of noninduced preparations (0.220\u2009\u00b1\u20090.1017 vs 0.128\u2009\u00b1\u20090.0312, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The transmural and epicardial dispersion of repolarization of pVT\u2010induced preparations were larger than those of pVT\u2010noninduced preparations. The transmural dispersion of repolarization showed a positive correlation with T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> predicted malignant ventricular arrhythmias in early repolarization syndrome models. T<jats:sub>peak<\/jats:sub>\u2013T<jats:sub>end<\/jats:sub> reflects the repolarization heterogeneity of ventricular myocardium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14123","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T11:00:15Z","timestamp":1566212415000},"page":"2098-2105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Experimental verification of the value of the T<sub>peak<\/sub>\u2013T<sub>end<\/sub> interval in ventricular arrhythmia inducibility in an early repolarization syndrome model"],"prefix":"10.1111","volume":"30","author":[{"given":"Namsik","family":"Yoon","sequence":"first","affiliation":[{"name":"Heart Center of Chonnam National University Hospital Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo Na","family":"Hong","sequence":"additional","affiliation":[{"name":"Heart Center of Chonnam National University Hospital Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-4490","authenticated-orcid":false,"given":"Jeong Gwan","family":"Cho","sequence":"additional","affiliation":[{"name":"Heart Center of Chonnam National University Hospital Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Ki","family":"Jeong","sequence":"additional","affiliation":[{"name":"Heart Center of Chonnam National University Hospital Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hong","family":"Lee","sequence":"additional","affiliation":[{"name":"Heart Center of Chonnam National University Hospital Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Heart Center of Chonnam National University Hospital Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2014.12.020"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux281"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.601690"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.10.017"},{"key":"e_1_2_7_1_6_1","first-page":"1866","article-title":"Tpeak\u2010Tend interval and Tpeak\u2010Tend\/QT ratio in patients with Brugada syndrome","volume":"18","author":"Zumhagen 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