{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:40:54Z","timestamp":1768560054434,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiovasc electrophysiol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Selection of an appropriate antithrombotic regimen in patients requiring oral anticoagulation (OAC) undergoing percutaneous coronary intervention (PCI) still remains a challenge. An ideal 9\u20132regimen should balance the risk of bleeding against ischemic benefit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search for studies comparing triple antithrombotic therapy (TAT) vs double antithrombotic therapy (DAT) in patients requiring OAC undergoing PCI was performed in clinicalTrials.gov, PubMed, Web of Science, EBSCO Services, Cochrane Central Register of Controlled Trials, Google Scholar, and various scientific conference sessions from inception to May 1st, 2019. A meta\u2010analysis was performed using random\u2010effects model to calculate risk ratio (RR) and 95% confidence interval (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies were eligible and included 13\u2009967 patients, of which 7349 received TAT and 6618 received DAT. Compared with DAT, TAT was associated with lower risk of myocardial infarction (RR, 0.82; 95%CI, 0.69\u20130.98; <jats:italic>P<\/jats:italic>\u2009=\u2009.03) and stent thrombosis (RR, 0.66; 95%CI, 0.46\u20130.96; <jats:italic>P<\/jats:italic>\u2009=\u2009.03). There was no difference in risk of trial defined major adverse cardiac events, all\u2010cause mortality, and stroke between two groups. Compared with DAT, TAT was associated with higher risk of trial defined major bleeding (RR, 1.67; 95%CI, 1.38\u20132.01; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001), including thrombolysis in myocardial infarction major bleeding (RR, 1.81; 95%CI, 1.47\u20132.24; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001) but no significant difference in risk of intracranial bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients requiring OAC undergoing PCI, TAT was associated with a lower risk of myocardial infarction but with a significantly higher risk of major bleeding when compared with DAT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jce.14132","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T05:09:56Z","timestamp":1566364196000},"page":"2460-2472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of single vs dual antiplatelet therapy in patients on anticoagulation undergoing percutaneous coronary intervention: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-1545","authenticated-orcid":false,"given":"Varunsiri","family":"Atti","sequence":"first","affiliation":[{"name":"Department of Medicine Michigan State University\u2010Sparrow Hospital East Lansing Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohit K.","family":"Turagam","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Icahn School of Medicine at Mount Sinai New York City New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalaj","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Icahn School of Medicine at Mount Sinai New York City New 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Lansing Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supratik","family":"Rayamajhi","sequence":"additional","affiliation":[{"name":"Department of Medicine Michigan State University\u2010Sparrow Hospital East Lansing Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S","family":"Abela","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases, Department of Medicine Michigan State University East Lansing Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Koerber","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of South Carolina Medical Center Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Gopinnathanair","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Kansas City Heart Rhythm Institute and Research Foundation Kansas 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